Molecular Pathology

Notably, immunofluorescence techniques invented by Albert Coons in 1961permitted detection of proteins in cells and tissues, [2] and in 1975, Edwin Southern invented the Southern blot to hybridize probes to specific DNA sequences and used the technique to identify a particular genetic polymorphism c...

Full description

Saved in:
Bibliographic Details
Published in:Journal of translational medicine 2024-01, Vol.22 (1), p.91-2, Article 91
Main Author: Warren, Sarah
Format: Article
Language:English
Subjects:
Analysis
Artificial intelligence
Biopsy
Data analysis
DNA probes
Fluorescent antibody technique
Gene polymorphism
Health aspects
Immunofluorescence
Immunology
Medical innovations
Mutation
Nucleotide sequence
Pathology
Pathology, Molecular
Polymorphism
Retinitis pigmentosa
Spatial discrimination
Technology application
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Notably, immunofluorescence techniques invented by Albert Coons in 1961permitted detection of proteins in cells and tissues, [2] and in 1975, Edwin Southern invented the Southern blot to hybridize probes to specific DNA sequences and used the technique to identify a particular genetic polymorphism co-occurring with X-linked retinitis pigmentosa [3]. Recent advances in molecular pathology, especially the development of profiling systems with higher resolution (including spatial resolution), higher plex, and ability to characterize multiple analytes from a single sample, are continuing to push the field forward. Parallel advances in statistical methods and artificial intelligence/machine learning approaches for data analysis will also drive greater biological insights and ultimately advances in patient care.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-024-04868-7