Circulating Inhibitor against Factor X: A Rare Cause of Hemorrhagic Diathesis

Acquired coagulopathies resulting from factor X deficiency are rare and typically associated with amyloidosis or plasma cell dyscrasia. Factor X plays a pivotal role in the coagulation cascade, converting prothrombin into thrombin and facilitating the formation of fibrinogen and thrombus. While its...

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Bibliographic Details
Published in:Case reports in hematology 2023-12, Vol.2023, p.5510654-6
Main Authors: Rossignon, P., Grandjean, F., Claessens, A., Weynants, N.
Format: Article
Language:English
Subjects:
Amyloidosis
Antibodies
Anticoagulants
Automation
Bacterial pneumonia
Blood
Blood clot
Blood clots
Blood coagulation factors
Case Report
Corticosteroids
Defects
Fibrin
Health aspects
Hemoglobin
Immunoglobulins
Laboratories
Liver diseases
Lupus
Medical examination
Methylprednisolone
Plasma
Pneumonia
Reagents
Thrombosis
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Summary:Acquired coagulopathies resulting from factor X deficiency are rare and typically associated with amyloidosis or plasma cell dyscrasia. Factor X plays a pivotal role in the coagulation cascade, converting prothrombin into thrombin and facilitating the formation of fibrinogen and thrombus. While its occurrence following common infections is extremely rare, isolated cases have been documented. We present a rare case of bleeding diathesis in a patient with community-acquired pneumonia, where prolonged activated partial thromboplastin time (aPTT) and prothrombin time (PT) led to the diagnosis of an infectious-triggered acquired circulating inhibitor targeting factor X. Prompt treatment with methylprednisolone effectively controlled the inhibitor without recurrence. This case report provides insights into the diagnostic strategies, differential algorithm, and therapeutic approaches for managing this rare coagulopathy.
ISSN:2090-6560
2090-6579
DOI:10.1155/2023/5510654