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Gene-Environment Interactions in Irrational Beliefs: The Roles of Childhood Adversity and Multiple Candidate Genes

Cognitive behavioral therapy is based on the view that maladaptive thinking is the causal mechanism of mental disorders. While this view is supported by extensive evidence, very limited work has addressed the factors that contribute to the development of maladaptive thinking. The present study aimed...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-04, Vol.25 (8), p.4206
Main Authors: Chiș, Adina, Oltean, Lia-Ecaterina, Bîlc, Mirela, Vulturar, Romana, Șoflău, Radu, David, Daniel, Szentágotai-Tătar, Aurora, Miu, Andrei C
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Language:English
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Summary:Cognitive behavioral therapy is based on the view that maladaptive thinking is the causal mechanism of mental disorders. While this view is supported by extensive evidence, very limited work has addressed the factors that contribute to the development of maladaptive thinking. The present study aimed to uncover interactions between childhood maltreatment and multiple genetic differences in irrational beliefs. Childhood maltreatment and irrational beliefs were assessed using multiple self-report instruments in a sample of healthy volunteers ( = 452). Eighteen single-nucleotide polymorphisms were genotyped in six candidate genes related to neurotransmitter function ( ; ; ), neurotrophic factors ( ), and the hypothalamic-pituitary-adrenal axis ( ; ). Gene-environment interactions (G×E) were first explored in models that employed one measure of childhood maltreatment and one measure of irrational beliefs. These effects were then followed up in models in which either the childhood maltreatment measure, the irrational belief measure, or both were substituted by parallel measures. Consistent results across models indicated that childhood maltreatment was positively associated with irrational beliefs, and these relations were significantly influenced by rs165774 and rs53576. These results remain preliminary until independent replication, but they represent the best available evidence to date on G×E in a fundamental mechanism of psychopathology.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25084206