Role of antioxidants and a nutrient rich diet in Alzheimer's disease

The joint attack on the body by metabolic acidosis and oxidative stress suggests that treatment in degenerative diseases, including Alzheimer's disease (AD), may require a normalizing of extracellular and intracellular pH with simultaneous supplementation of an antioxidant combination cocktail...

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Bibliographic Details
Published in:Open biology 2020-06, Vol.10 (6), p.200084
Main Authors: Veurink, Gerald, Perry, George, Singh, Sandeep Kumar
Format: Article
Language:English
Subjects:
Alzheimer Disease - drug therapy
alzheimer's disease
antioxidant
Antioxidants - pharmacology
Antioxidants - therapeutic use
Diet
Dietary Supplements
Drug Synergism
Humans
neuroprotection
nutraceutical
nutrient
oxidative stress
Oxidative Stress - drug effects
Review
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Summary:The joint attack on the body by metabolic acidosis and oxidative stress suggests that treatment in degenerative diseases, including Alzheimer's disease (AD), may require a normalizing of extracellular and intracellular pH with simultaneous supplementation of an antioxidant combination cocktail at a sufficiently high dose. Evidence is also accumulating that combinations of antioxidants may be more effective, taking advantage of synergistic effects of appropriate antioxidants as well as a nutrient-rich diet to prevent and reverse AD. This review focuses on nutritional, nutraceutical and antioxidant treatments of AD, although they can also be used in other chronic degenerative and neurodegenerative diseases.
ISSN:2046-2441
2046-2441
DOI:10.1098/rsob.200084