Neonatal Hypoglycemia Related to Glycine Levels in Uncontrolled Gestational Diabetes Mellitus during Mid-Late Pregnancy: Multicenter, Prospective Case-Cohort Observational Study

Aims. To explore the relationship between gestational diabetes mellitus (GDM) and neonatal cord blood amino acid and carnitine levels after GDM was diagnosed among pregnant women monitoring glycosylated haemoglobin levels of 5.5%-6.4% during mid-late gestation. Methods. In all, 7289 qualified partic...

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Bibliographic Details
Published in:Journal of diabetes research 2020, Vol.2020 (2020), p.1-11
Main Authors: Jiang, Fangfang, Wang, Jianying, Chen, Yao, Cao, Jianyong, Xie, Dan, Su, Zhaojuan, Chen, WuJuan, Liu, Meijun, Bao, Xin, Zhang, Hanxi, Liu, Wei, Yang, Yaochao, Chen, Le, Long, Yuhang, Hong, Ting
Format: Article
Language:English
Subjects:
Amino acids
Blood tests
Cholesterol
Gestational diabetes
Glucose
Hemoglobin
Hyperglycemia
Hypoglycemia
Insulin resistance
Laboratories
Lipids
Lipoproteins
Maternal & child health
Metabolism
Metabolites
Newborn babies
Observational studies
Pregnancy
Sample size
Womens health
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Summary:Aims. To explore the relationship between gestational diabetes mellitus (GDM) and neonatal cord blood amino acid and carnitine levels after GDM was diagnosed among pregnant women monitoring glycosylated haemoglobin levels of 5.5%-6.4% during mid-late gestation. Methods. In all, 7289 qualified participants were recruited and divided into two groups (GDM and control groups) between 1 July 2015 and 1 July 2020, and all maternal-neonatal data were collected and analyzed at three centers. Results. Interestingly, glycine in cord blood was not only significantly different between groups (15.52 vs. 6.67, P
ISSN:2314-6745
2314-6753
DOI:10.1155/2020/9502870