Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value 6000 Latin Americans identifies novel genomic regions influ...

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Published in:Communications biology 2023-05, Vol.6 (1), p.481-13, Article 481
Main Authors: Li, Qing, Chen, Jieyi, Faux, Pierre, Delgado, Miguel Eduardo, Bonfante, Betty, Fuentes-Guajardo, Macarena, Mendoza-Revilla, Javier, Chacón-Duque, J. Camilo, Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Jaramillo, Claudia, Arias, William, Barquera, Rodrigo, Everardo-Martínez, Paola, Sánchez-Quinto, Mirsha, Gómez-Valdés, Jorge, Villamil-Ramírez, Hugo, Silva de Cerqueira, Caio C., Hünemeier, Tábita, Ramallo, Virginia, Wu, Sijie, Du, Siyuan, Giardina, Andrea, Paria, Soumya Subhra, Khokan, Mahfuzur Rahman, Gonzalez-José, Rolando, Schüler-Faccini, Lavinia, Bortolini, Maria-Cátira, Acuña-Alonzo, Victor, Canizales-Quinteros, Samuel, Gallo, Carla, Poletti, Giovanni, Rojas, Winston, Rothhammer, Francisco, Navarro, Nicolas, Wang, Sijia, Adhikari, Kaustubh, Ruiz-Linares, Andrés
Format: Article
Language:English
Subjects:
45
45/43
631/208/205/2138
631/208/480
Animals
Biodiversity
Biological anthropology
Biology
Biomedical and Life Sciences
Cell Differentiation
Craniofacial growth
Genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Hominids
Human genetics
Humanities and Social Sciences
Humans
Life Sciences
Mice
Morphology
Neanderthals
Neanderthals - genetics
Neural crest
Nose
Populations and Evolution
Regulatory sequences
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Summary:We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value 6000 Latin Americans identifies novel genomic regions influencing facial features and implicates Neanderthal introgression in nasal shape.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-023-04838-7