Stem cells as potential therapeutics for hearing loss

Hearing impairment is a global health problem. Stem cell therapy has become a cutting-edge approach to tissue regeneration. In this review, the recent advances in stem cell therapy for hearing loss have been discussed. Nanomaterials can modulate the stem cell microenvironment to augment the therapeu...

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Bibliographic Details
Published in:Frontiers in neuroscience 2023-09, Vol.17, p.1259889-1259889
Main Authors: Fang, Qiaojun, Wei, Yongjie, Zhang, Yuhua, Cao, Wei, Yan, Lin, Kong, Mengdie, Zhu, Yongjun, Xu, Yan, Guo, Lingna, Zhang, Lei, Wang, Weiqing, Yu, Yafeng, Sun, Jingwu, Yang, Jianming
Format: Article
Language:English
Subjects:
clinical trial
exosomes
hearing loss
nanomaterials
Neuroscience
stem cells
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Summary:Hearing impairment is a global health problem. Stem cell therapy has become a cutting-edge approach to tissue regeneration. In this review, the recent advances in stem cell therapy for hearing loss have been discussed. Nanomaterials can modulate the stem cell microenvironment to augment the therapeutic effects further. The potential of combining nanomaterials with stem cells for repairing and regenerating damaged inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) has also been discussed. Stem cell-derived exosomes can contribute to the repair and regeneration of damaged tissue, and the research progress on exosome-based hearing loss treatment has been summarized as well. Despite stem cell therapy’s technical and practical limitations, the findings reported so far are promising and warrant further investigation for eventual clinical translation.
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2023.1259889