CA 15-3 prognostic biomarker in SARS-CoV-2 pneumonia

The severity of lung involvement is the main prognostic factor in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Carbohydrate antigen 15-3 (CA 15-3), a marker of lung damage and fibrosis, could help predict the prognosis of SARS-CoV-2 pneumonia. This was a retrospective and...

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Published in:Scientific reports 2022-04, Vol.12 (1), p.6738-6738, Article 6738
Main Authors: Ros-Lucas, José Antonio, Pascual-Figal, Domingo Andrés, Noguera-Velasco, José Antonio, Hernández-Vicente, Álvaro, Cebreiros-López, Iria, Arnaldos-Carrillo, María, Martínez-Ardil, Isabel M., García-Vázquez, Elisa, Aparicio-Vicente, Mario, Solana-Martínez, Elena, Ruiz-Martínez, Sheyla Yolany, Fernández-Mula, Laura, Andujar-Espinosa, Rubén, Fernández-Suarez, Beatriz, Sánchez-Caro, Maria Dolores, Peñalver-Mellado, Carlos, Ruiz-López, Francisco José
Format: Article
Language:English
Subjects:
692/53/2422
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Adult
Aged
Biomarkers
Blood
C-Reactive Protein
Calcium-binding protein
Coronaviruses
COVID-19
COVID-19 - diagnosis
Female
Fibrosis
Humanities and Social Sciences
Humans
Intensive care
Interleukin 6
Male
Middle Aged
Mucin-1
multidisciplinary
Observational studies
Oxygen
Patients
Pneumonia
Prognosis
Retrospective Studies
Risk factors
SARS-CoV-2
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Troponin
Troponin T
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Summary:The severity of lung involvement is the main prognostic factor in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Carbohydrate antigen 15-3 (CA 15-3), a marker of lung damage and fibrosis, could help predict the prognosis of SARS-CoV-2 pneumonia. This was a retrospective and observational study. CA 15-3 was analyzed in the blood samples of patients consecutively admitted for SARS-CoV-2 pneumonia and whose blood samples were available in the biobank. Other prognostic markers were also measured (interleukin 6 [IL6], C-reactive protein [CRP], D-dimer, troponin T, and NT-ProBNP). The occurrence of in-hospital complications was registered, including death, the need for medical intensive care, and oxygen therapy at discharge. In this study, 539 patients were recruited (54.9% men, mean age: 59.6 ± 16.4 years). At admission, the mean concentrations of CA 15-3 was 20.5 ± 15.8 U/mL, and the concentration was correlated with male sex, older age, and other severity markers of coronavirus disease of 2019 (COVID-19) (IL6, CRP, D-dimer, troponine T, and NT-ProBNP). CA 15-3 levels were higher in patients who died (n = 56, 10.4%) (35.33 ± 30.45 vs. 18.8 ± 12.11, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-10726-7