Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis

The chemical investigation of the organic extract of collected at Drunken Man's Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4 -acetoxy-8 ,9 -epoxy-14 -hydroxy-7-oxodolastane ( ) and 4 -hydroxy-8 ,9 -epoxy-14 -hydroxy-7-oxodolastane ( ) and the previously...

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Bibliographic Details
Published in:Marine drugs 2017-05, Vol.15 (6), p.150
Main Authors: Campbell, Sanjay, Murray, JeAnn, Delgoda, Rupika, Gallimore, Winklet
Format: Article
Language:English
Subjects:
Canistrocarpus cervicornis
Cell Line, Tumor
Cell lines
Cytotoxicity
Diterpenes
Diterpenes - chemistry
dolastane
Epoxy compounds
HT29 Cells
Humans
Neoplasms
Organic chemistry
Phaeophyceae - chemistry
Seaweed - chemistry
Toxicity
Tumor cell lines
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Summary:The chemical investigation of the organic extract of collected at Drunken Man's Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4 -acetoxy-8 ,9 -epoxy-14 -hydroxy-7-oxodolastane ( ) and 4 -hydroxy-8 ,9 -epoxy-14 -hydroxy-7-oxodolastane ( ) and the previously isolated dolastane (4 ,9 ,14 )-4,9,14-trihydroxydolast-1(15),7-diene ( ) as a major diterpene constituent. The structures of the new compounds were elucidated by extensive spectroscopic analyses. Compounds - were evaluated for their cytotoxicity against human tumor cell lines PC3 and HT29. The results revealed that the dolastane diterpenes ( - ) displayed moderate, concentration dependent, cytotoxicity.
ISSN:1660-3397
1660-3397
DOI:10.3390/md15060150