Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients

A severe systemic inflammatory response is usually seen after burn injury. IL-18 enhances the Th1 immune responses in bacterial andviral infections. In order to evaluate the IL-18 serum levels as well as IL-6 and TNF-alpha at the 48th hour postburn, serial serum samples of 8 burned patients were ana...

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Bibliographic Details
Published in:Mediators of Inflammation 2006-01, Vol.2006 (2), p.49-52
Main Authors: COBAN, Y. Kenan, ARAL, Murat
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Body Mass Index
Burns
Burns - blood
Burns - immunology
Burns and scalds
Care and treatment
Cytokines - metabolism
Female
Humans
Immune System - pathology
Inflammation
Interleukin-18
Interleukin-18 - blood
Interleukin-6 - blood
Male
Medical sciences
Short Communication
Time Factors
Traumas. Diseases due to physical agents
Tumor Necrosis Factor-alpha - blood
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Description
Summary:A severe systemic inflammatory response is usually seen after burn injury. IL-18 enhances the Th1 immune responses in bacterial andviral infections. In order to evaluate the IL-18 serum levels as well as IL-6 and TNF-alpha at the 48th hour postburn, serial serum samples of 8 burned patients were analyzed. 8 moderately burned patients were included into the study. Serum samples were taken at admission at the 48th hour of postburn. IL-6, IL-18, and TNF-alpha serum levels were analyzed. Total mean burned surface area (TBSA) was 24.6 +/- 5.7% and mean BMI (body mass index) was 24.5 +/- 3.4. The patients' age ranged from 17 to 38 (mean 26.3 +/- 7.4) years. An increase in sera IL-6, IL-18, and TNF-alpha was detected at the 48th hour postburn (P < .0001). All patients survived. A marked increase in serum levels of IL-18 as well as the other cytokines evaluated was observed in the moderately burned patients. These three parameters were highly correlated with each other (r > 0.9 and P < .001). This is the first study that shows an increase in serum IL-18 levels at the early postburn period.
ISSN:0962-9351
1466-1861
DOI:10.1155/MI/2006/16492