Delivery-mediated exosomal therapeutics in ischemia–reperfusion injury: advances, mechanisms, and future directions

Ischemia-reperfusion injury (IRI) poses significant challenges across various organ systems, including the heart, brain, and kidneys. Exosomes have shown great potentials and applications in mitigating IRI-induced cell and tissue damage through modulating inflammatory responses, enhancing angiogenes...

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Bibliographic Details
Published in:Nano convergence 2024-04, Vol.11 (1), p.18-18, Article 18
Main Authors: Ding, Shengzhe, Kim, Yu-Jin, Huang, Kai-Yu, Um, Daniel, Jung, Youngmee, Kong, Hyunjoon
Format: Article
Language:English
Subjects:
Angiogenesis
Antioxidants
Brain research
Cell death
Chemistry and Materials Science
Hypothermia
Ischemia
Kidneys
Materials Science
Metabolism
MicroRNAs
Mitochondria
Mitochondrial DNA
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
Oxidative stress
Review
Stem cells
Traumatic brain injury
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Summary:Ischemia-reperfusion injury (IRI) poses significant challenges across various organ systems, including the heart, brain, and kidneys. Exosomes have shown great potentials and applications in mitigating IRI-induced cell and tissue damage through modulating inflammatory responses, enhancing angiogenesis, and promoting tissue repair. Despite these advances, a more systematic understanding of exosomes from different sources and their biotransport is critical for optimizing therapeutic efficacy and accelerating the clinical adoption of exosomes for IRI therapies. Therefore, this review article overviews the administration routes of exosomes from different sources, such as mesenchymal stem cells and other somatic cells, in the context of IRI treatment. Furthermore, this article covers how the delivered exosomes modulate molecular pathways of recipient cells, aiding in the prevention of cell death and the promotions of regeneration in IRI models. In the end, this article discusses the ongoing research efforts and propose future research directions of exosome-based therapies. Graphical Abstract
ISSN:2196-5404
2196-5404
DOI:10.1186/s40580-024-00423-8