A comprehensive analysis of the immune system in healthy Vietnamese people

Lifestyle, diet, socioeconomic status and genetics all contribute to heterogeneity in immune responses. Vietnam is plagued with a variety of health problems, but there are no available data on immune system values in the Vietnamese population. This study aimed to establish reference intervals for im...

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Bibliographic Details
Published in:Heliyon 2024-05, Vol.10 (9), p.e30647-e30647, Article e30647
Main Authors: Huynh, Dinh Chien, Nguyen, Minh Phuong, Ngo, Dinh Trung, Nguyen, Xuan Hung, Nguyen, Dac Tu, Mai, Thi Hien, Le, Thi Huyen, Hoang, Mai Duy, Le, Khac Linh, Nguyen, Khoi Quan, Nguyen, Viet Hoang, Kelley, Keith W.
Format: Article
Language:English
Subjects:
blood serum
chemokines
Cytokines
diet
flow cytometry
genetics
humans
Immune system
leukocyte count
lifestyle
Lymphocyte subset markers
Multi-color flow cytometry
socioeconomic status
Vietnam
Vietnamese people
Vietnamese population
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Summary:Lifestyle, diet, socioeconomic status and genetics all contribute to heterogeneity in immune responses. Vietnam is plagued with a variety of health problems, but there are no available data on immune system values in the Vietnamese population. This study aimed to establish reference intervals for immune cell parameters specific to the healthy Vietnamese population by utilizing multi-color flow cytometry (MCFC). We provide a comprehensive analysis of total leukocyte count, quantitative and qualitative shifts within lymphocyte subsets, serum and cytokine and chemokine levels and functional attributes of key immune cells including B cells, T cells, natural killer (NK) cells and their respective subpopulations. By establishing these reference values for the Vietnamese population, these data contribute significantly to our understanding of the human immune system variations across diverse populations. These data will be of substantial comparative value and be instrumental in developing personalized medical approaches and optimizing diagnostic strategies for individuals based on their unique immune profiles. •Establishing reference intervals for immune cell parameters in the Vietnamese population using multi-color flow cytometry.•Comprehensive analysis of molecular and cellular immune system parameters.•There is no difference in gender but there is an effect of age on immunological aspects found in healthy Vietnamese people.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e30647