Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study

• Published in: Scientific reports 2021-05, Vol.11 (1), p.9994-9994, Article 9994
• Main Authors: Kobayashi, Sumitaka, Sata, Fumihiro, Goudarzi, Houman, Araki, Atsuko, Miyashita, Chihiro, Sasaki, Seiko, Okada, Emiko, Iwasaki, Yusuke, Nakajima, Tamie, Kishi, Reiko
• Format: Article
• Language: English
• Subjects: 692/499; 704/172; Chromatography; Gas chromatography; Gene polymorphism; Genotype-environment interactions; Genotypes; Humanities and Social Sciences; Liquid chromatography; Mass spectrometry; Mass spectroscopy; multidisciplinary; Nuclear receptors; Oleic acid; Palmitic acid; Perfluorooctanoic acid; Peroxisome proliferator-activated receptors; Science; Science (multidisciplinary); Scientific imaging; Single-nucleotide polymorphism; Triglycerides
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-89285-2

The effect of interactions between perfluorooctanesulfonic (PFOS)/perfluorooctanoic acid (PFOA) levels and nuclear receptor genotypes on fatty acid (FA) levels, including those of triglycerides, is not clear understood. Therefore, in the present study, we aimed to analyse the association of PFOS/PFOA levels and single-nucleotide polymorphisms (SNPs) in nuclear receptors with FA levels in pregnant women. We analysed 504 mothers in a birth cohort between 2002 and 2005 in Japan. Serum PFOS/PFOA and FA levels were measured using liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Maternal genotypes in PPARA (rs1800234; rs135561), PPARG (rs3856806), PPARGC1A (rs2970847; rs8192678), PPARD (rs1053049; rs2267668), CAR (rs2307424; rs2501873), LXRA (rs2279238) and LXRB (rs1405655; rs2303044; rs4802703) were analysed. When gene-environment interaction was considered, PFOS exposure (log 10 scale) decreased palmitic, palmitoleic, and oleic acid levels (log 10 scale), with the observed β in the range of − 0.452 to − 0.244; PPARGC1A (rs8192678) and PPARD (rs1053049; rs2267668) genotypes decreased triglyceride, palmitic, palmitoleic, and oleic acid levels, with the observed β in the range of − 0.266 to − 0.176. Interactions between PFOS exposure and SNPs were significant for palmitic acid ( P int  = 0.004 to 0.017). In conclusion, the interactions between maternal PFOS levels and PPARGC1A or PPARD may modify maternal FA levels.