Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study

The effect of interactions between perfluorooctanesulfonic (PFOS)/perfluorooctanoic acid (PFOA) levels and nuclear receptor genotypes on fatty acid (FA) levels, including those of triglycerides, is not clear understood. Therefore, in the present study, we aimed to analyse the association of PFOS/PFO...

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Published in:Scientific reports 2021-05, Vol.11 (1), p.9994-9994, Article 9994
Main Authors: Kobayashi, Sumitaka, Sata, Fumihiro, Goudarzi, Houman, Araki, Atsuko, Miyashita, Chihiro, Sasaki, Seiko, Okada, Emiko, Iwasaki, Yusuke, Nakajima, Tamie, Kishi, Reiko
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692/499
704/172
Chromatography
Gas chromatography
Gene polymorphism
Genotype-environment interactions
Genotypes
Humanities and Social Sciences
Liquid chromatography
Mass spectrometry
Mass spectroscopy
multidisciplinary
Nuclear receptors
Oleic acid
Palmitic acid
Perfluorooctanoic acid
Peroxisome proliferator-activated receptors
Science
Science (multidisciplinary)
Scientific imaging
Single-nucleotide polymorphism
Triglycerides
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creator Kobayashi, Sumitaka
Sata, Fumihiro
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Nakajima, Tamie
Kishi, Reiko
description The effect of interactions between perfluorooctanesulfonic (PFOS)/perfluorooctanoic acid (PFOA) levels and nuclear receptor genotypes on fatty acid (FA) levels, including those of triglycerides, is not clear understood. Therefore, in the present study, we aimed to analyse the association of PFOS/PFOA levels and single-nucleotide polymorphisms (SNPs) in nuclear receptors with FA levels in pregnant women. We analysed 504 mothers in a birth cohort between 2002 and 2005 in Japan. Serum PFOS/PFOA and FA levels were measured using liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Maternal genotypes in PPARA (rs1800234; rs135561), PPARG (rs3856806), PPARGC1A (rs2970847; rs8192678), PPARD (rs1053049; rs2267668), CAR (rs2307424; rs2501873), LXRA (rs2279238) and LXRB (rs1405655; rs2303044; rs4802703) were analysed. When gene-environment interaction was considered, PFOS exposure (log 10 scale) decreased palmitic, palmitoleic, and oleic acid levels (log 10 scale), with the observed β in the range of − 0.452 to − 0.244; PPARGC1A (rs8192678) and PPARD (rs1053049; rs2267668) genotypes decreased triglyceride, palmitic, palmitoleic, and oleic acid levels, with the observed β in the range of − 0.266 to − 0.176. Interactions between PFOS exposure and SNPs were significant for palmitic acid ( P int  = 0.004 to 0.017). In conclusion, the interactions between maternal PFOS levels and PPARGC1A or PPARD may modify maternal FA levels.
doi_str_mv 10.1038/s41598-021-89285-2
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Therefore, in the present study, we aimed to analyse the association of PFOS/PFOA levels and single-nucleotide polymorphisms (SNPs) in nuclear receptors with FA levels in pregnant women. We analysed 504 mothers in a birth cohort between 2002 and 2005 in Japan. Serum PFOS/PFOA and FA levels were measured using liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Maternal genotypes in PPARA (rs1800234; rs135561), PPARG (rs3856806), PPARGC1A (rs2970847; rs8192678), PPARD (rs1053049; rs2267668), CAR (rs2307424; rs2501873), LXRA (rs2279238) and LXRB (rs1405655; rs2303044; rs4802703) were analysed. When gene-environment interaction was considered, PFOS exposure (log 10 scale) decreased palmitic, palmitoleic, and oleic acid levels (log 10 scale), with the observed β in the range of − 0.452 to − 0.244; PPARGC1A (rs8192678) and PPARD (rs1053049; rs2267668) genotypes decreased triglyceride, palmitic, palmitoleic, and oleic acid levels, with the observed β in the range of − 0.266 to − 0.176. Interactions between PFOS exposure and SNPs were significant for palmitic acid ( P int  = 0.004 to 0.017). 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Therefore, in the present study, we aimed to analyse the association of PFOS/PFOA levels and single-nucleotide polymorphisms (SNPs) in nuclear receptors with FA levels in pregnant women. We analysed 504 mothers in a birth cohort between 2002 and 2005 in Japan. Serum PFOS/PFOA and FA levels were measured using liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Maternal genotypes in PPARA (rs1800234; rs135561), PPARG (rs3856806), PPARGC1A (rs2970847; rs8192678), PPARD (rs1053049; rs2267668), CAR (rs2307424; rs2501873), LXRA (rs2279238) and LXRB (rs1405655; rs2303044; rs4802703) were analysed. 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subjects 692/499
704/172
Chromatography
Gas chromatography
Gene polymorphism
Genotype-environment interactions
Genotypes
Humanities and Social Sciences
Liquid chromatography
Mass spectrometry
Mass spectroscopy
multidisciplinary
Nuclear receptors
Oleic acid
Palmitic acid
Perfluorooctanoic acid
Peroxisome proliferator-activated receptors
Science
Science (multidisciplinary)
Scientific imaging
Single-nucleotide polymorphism
Triglycerides
title Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study
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