Preparation of PLA/chitosan nanoscaffolds containing cod liver oil and experimental diabetic wound healing in male rats study

Diabetes mellitus is one of the most common metabolic disorders. One of the important metabolic complications in diabetes is diabetic foot ulcer syndrome, which causes delayed and abnormal healing of the wound. The formulation of nanoscaffolds containing cod liver oil by altering the hemodynamic bal...

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Published in:Journal of nanobiotechnology 2020-11, Vol.18 (1), p.1-176, Article 176
Main Authors: Khazaeli, Payam, Alaei, Maryam, Khaksarihadad, Mohammad, Ranjbar, Mehdi
Format: Article
Language:English
Subjects:
Care and treatment
Chemical analysis
Chitin
Chitosan
Cod liver oil
Codfish
Complications
Composition effects
Diabetes
Diabetes mellitus
Diabetic foot ulcer
Drug delivery systems
Electron microscopy
Electrospinning
Fatty acids
Feet
Fish oils
Fourier transforms
Functional groups
Hemodynamics
Inflammation
Infrared analysis
Infrared spectroscopy
Lactic acid
Light scattering
Liver
Membranes
Metabolic disorders
Methods
Nanoparticles
Nanotechnology
Optical properties
Pharmaceuticals
Phospholipids
Photon correlation spectroscopy
Physiological aspects
Physiology
Poly lactic acid/chitosan nanoscaffolds
Polyesters
Polylactic acid
Polymers
Production processes
Scanning electron microscopy
Transmission electron microscopy
Vasodilators
Wound healing
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description Diabetes mellitus is one of the most common metabolic disorders. One of the important metabolic complications in diabetes is diabetic foot ulcer syndrome, which causes delayed and abnormal healing of the wound. The formulation of nanoscaffolds containing cod liver oil by altering the hemodynamic balance toward the vasodilators state, increasing wound blood supply, and altering plasma membrane properties, namely altering the membrane phospholipids composition, can be effective in wound healing. In this study, electrospinning method was used to produce poly lactic acid/chitosan nanoscaffolds as a suitable bio-substitute. After preparing the nanoscaffolds, the products were characterized with dynamic light scattering (DLS), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Also optical properties of polymer and comparison between adsorption between single polymer and polymer-drug calculated with UV−Vis spectra. The structure and functional groups of the final products were characterized by Fourier-transform infrared spectroscopy (FT-IR) and energy dispersive spectroscopy (EDAX) as elemental analysis. The results showed that the optimum formulation of cod liver oil was 30%, which formed a very thin fiber that rapidly absorbed to the wound and produced significant healing effects. According to the results, poly lactic acid/chitosan nanoscaffolds containing cod liver oil can be a suitable bio-product to be used in treating the diabetic foot ulcer syndrome.
doi_str_mv 10.1186/s12951-020-00737-9
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One of the important metabolic complications in diabetes is diabetic foot ulcer syndrome, which causes delayed and abnormal healing of the wound. The formulation of nanoscaffolds containing cod liver oil by altering the hemodynamic balance toward the vasodilators state, increasing wound blood supply, and altering plasma membrane properties, namely altering the membrane phospholipids composition, can be effective in wound healing. In this study, electrospinning method was used to produce poly lactic acid/chitosan nanoscaffolds as a suitable bio-substitute. After preparing the nanoscaffolds, the products were characterized with dynamic light scattering (DLS), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Also optical properties of polymer and comparison between adsorption between single polymer and polymer-drug calculated with UV−Vis spectra. The structure and functional groups of the final products were characterized by Fourier-transform infrared spectroscopy (FT-IR) and energy dispersive spectroscopy (EDAX) as elemental analysis. The results showed that the optimum formulation of cod liver oil was 30%, which formed a very thin fiber that rapidly absorbed to the wound and produced significant healing effects. According to the results, poly lactic acid/chitosan nanoscaffolds containing cod liver oil can be a suitable bio-product to be used in treating the diabetic foot ulcer syndrome.</abstract><cop>London</cop><pub>BioMed Central Ltd</pub><pmid>33256764</pmid><doi>10.1186/s12951-020-00737-9</doi><orcidid>https://orcid.org/0000-0002-5844-3299</orcidid><oa>free_for_read</oa></addata></record>
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subjects Care and treatment
Chemical analysis
Chitin
Chitosan
Cod liver oil
Codfish
Complications
Composition effects
Diabetes
Diabetes mellitus
Diabetic foot ulcer
Drug delivery systems
Electron microscopy
Electrospinning
Fatty acids
Feet
Fish oils
Fourier transforms
Functional groups
Hemodynamics
Inflammation
Infrared analysis
Infrared spectroscopy
Lactic acid
Light scattering
Liver
Membranes
Metabolic disorders
Methods
Nanoparticles
Nanotechnology
Optical properties
Pharmaceuticals
Phospholipids
Photon correlation spectroscopy
Physiological aspects
Physiology
Poly lactic acid/chitosan nanoscaffolds
Polyesters
Polylactic acid
Polymers
Production processes
Scanning electron microscopy
Transmission electron microscopy
Vasodilators
Wound healing
title Preparation of PLA/chitosan nanoscaffolds containing cod liver oil and experimental diabetic wound healing in male rats study
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