Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis

Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in the pathogenesis of rheumatoid arthritis (RA). However, limited data from studies about the activity of histone deacetylases (HDACs) and histone acetyltransferase (HAT) in RA are controversial. Those c...

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Bibliographic Details
Published in:Journal of immunology research 2018-01, Vol.2018 (2018), p.1-10
Main Authors: Shi, Guixiu, Wang, Dashan, Yuan, Xiaoqing, Wang, Mian, He, Yan, Zhang, Di, Song, Lina, Lv, Xiuying, Zhou, Mi, Li, Yan, Zhao, Xue
Format: Article
Language:English
Subjects:
Acetylation
Autoimmune diseases
Blood
Chromatin
Deacetylation
Disease
Epigenetics
Fibroblasts
Gene expression
Histone acetyltransferase
Histone deacetylase
Histone H3
Histones
Immunology
Leukocytes (mononuclear)
mRNA
Pathogenesis
Peripheral blood mononuclear cells
Proteins
Rheumatoid arthritis
Rheumatology
RNA polymerase
Studies
Tumor necrosis factor-TNF
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Summary:Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in the pathogenesis of rheumatoid arthritis (RA). However, limited data from studies about the activity of histone deacetylases (HDACs) and histone acetyltransferase (HAT) in RA are controversial. Those conflicting results may be caused by sample size, medication, and age- and sex-matched controls. The aim of this study is to investigate the expression and activity of class I HDACs (1–3.8) and their effects on histone acetylation in peripheral blood mononuclear cells (PBMCs) from RA patients. The expression of class I HDACs in PBMCs from RA patients was decreased in both mRNA and protein levels in comparison with HCs. The nuclear HAT activities were dramatically increased. Further, we found HDAC3 activity to be the most significantly reduced in overall reduction of HDACs in the RA group. The extent of total histone H3, but not H4, acetylation in PBMCs from RA patients was increased compared to that in healthy controls (HCs) (p
ISSN:2314-8861
2314-7156
DOI:10.1155/2018/7313515