Programmed Cell Death in the Pathogenesis of Influenza

Influenza is a respiratory disease induced by infection by the influenza virus, which is a member of family. This infectious disease has serious impacts on public health systems and results in considerable mortality and economic costs throughout the world. Based on several experimental studies, mass...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-07, Vol.19 (7), p.2065
Main Authors: Fujikura, Daisuke, Miyazaki, Tadaaki
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - immunology
Cell death
Cytokines - immunology
Cytokines - metabolism
Disease
Economic impact
Host-Pathogen Interactions - immunology
Humans
Infectious diseases
Inflammation - immunology
Inflammation - pathology
Inflammation - virology
Influenza
Influenza A virus - immunology
Influenza A virus - physiology
Influenza, Human - immunology
Influenza, Human - pathology
Influenza, Human - virology
Models, Immunological
Molecular modelling
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - pathology
Orthomyxoviridae Infections - virology
Pathogenesis
programmed cell death
Propagation
Public health
Review
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Summary:Influenza is a respiratory disease induced by infection by the influenza virus, which is a member of family. This infectious disease has serious impacts on public health systems and results in considerable mortality and economic costs throughout the world. Based on several experimental studies, massive host immune reaction is associated with the disease severity of influenza. Programmed cell death is typically induced during virus infection as a consequence of host immune reaction to limit virus spread by eliminating niches for virus propagation without causing inflammation. However, in some viral infectious diseases, such as influenza, in the process of immune reaction, aberrant induction of programmed cell death disturbs the maintenance of organ function. Current reports show that there are different types of programmed cell death that vary in terms of molecular mechanisms and/or associations with inflammation. In addition, these novel types of programmed cell death are associated with pathogenesis rather than suppressing virus propagation in the disease course. Here, we review our current understanding of mechanisms of programmed cell death in the pathogenesis of influenza.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19072065