Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease

[Display omitted] •The structures, bioactivities and mechanisms of phytoconstituents for the management of Huntington’s disease were mentioned.•Clinical trials conducted on some phytoconstituents and vitamins against Huntington’s disease were included.•Other medicinal properties of phytoconstituents...

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Published in:Journal of functional foods 2022-05, Vol.92, p.105047, Article 105047
Main Authors: Singh, Pradeep, Mishra, Garima, Molla, Mulugeta, Shumet Yimer, Yohannes, Sisay, Woretaw, Andargie, Yared, Ewunetie, Amien
Format: Article
Language:English
Subjects:
3-Nitropropionic Acid
Antioxidant
brain
cortex
death
dietary supplements
Excitotoxicity
health promotion
humans
Huntington's Disease
immunity
Mitochondrial Dysfunction
Mutant Huntingtin Protein
mutants
neurons
Nutraceuticals
Oxidative Stress
pathogenesis
pathophysiology
Quinolinic Acid
Striatum
therapeutics
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Summary:[Display omitted] •The structures, bioactivities and mechanisms of phytoconstituents for the management of Huntington’s disease were mentioned.•Clinical trials conducted on some phytoconstituents and vitamins against Huntington’s disease were included.•Other medicinal properties of phytoconstituents in concern were mentioned in the form of figure.•Pathophysiological mechanisms implicated in Huntington’s disease were elaborated. Among several neurodegenerative diseases, Huntington disease has posed a major threat across the world, particularly in the aged population. The disease is caused due to expansion of cytosine-adenine-guanine repeats which further triggers the formation of a mutant huntingtin protein responsible for neuronal death. Numerous pathophysiologic mechanisms have been implicated in Huntington’s disease. Striatum and cortex represent the most affected parts of the brain. Even though a wide range of medicines are available but they possess serious side effects. Therefore, the emergence of nutraceuticals derived from natural sources has received great attention in the pharmaceutical domain. Nutraceuticals are health-promoting supplements and enhance immunity in human beings. Currently, oxidative stress is the leading factor for chronic diseases that occur due to low intake of antioxidants. Herbal nutraceuticals are said to be enriched with a massive number of antioxidants. Therefore, this article throws light on various herbal nutraceuticals and their noteworthy effects on Huntington’s disease.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2022.105047