Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors

Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the pre...

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Published in:Diagnostics (Basel) 2022-12, Vol.12 (12), p.3105
Main Authors: Mitranovici, Melinda-Ildiko, Chiorean, Diana Maria, Mureșan, Maria Cezara, Buicu, Corneliu-Florin, Moraru, Raluca, Moraru, Liviu, Cotoi, Titiana Cornelia, Cotoi, Ovidiu Simion, Toru, Havva Serap, Apostol, Adrian, Turdean, Sabin Gligore, Mărginean, Claudiu, Petre, Ion, Oală, Ioan Emilian, Simon-Szabo, Zsuzsanna, Ivan, Viviana, Pușcașiu, Lucian
Format: Article
Language:English
Subjects:
Abdomen
Biomarkers
Biopsy
Care and treatment
Case reports
Chemotherapy
Diagnosis
dysgerminoma
epigenetics
Family medical history
Fertility
Germ cell tumors
Gynecology
Hemorrhage
heterogenous tumors
Hormone replacement therapy
Medical prognosis
Metastasis
OMGCTs
Ovaries
Pediatrics
platinum-based therapy
Pregnancy
primitive germ cell tumors
Prognosis
Review
Tomography
Tumors
Ultrasonic imaging
Y chromosomes
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Summary:Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the preservation of fertility. Even if a multidisciplinary team, founded in 2009 by a gynecologist, an oncologist, a pediatric oncologist and a pediatric surgeon, under the guidance of the Malignant Germ Cell International Consortium (MaGIC), studies this type of tumor, issues still remain related to the lack of a randomized study and to both the management and understanding of the concept of OMGCTs (ovarian malignant germ cell tumors). The aim of this review is to present from the literature the various approaches for this type of tumor, and, regarding innovative therapies or possible prevention, which can be applied in clinical practice. Multidisciplinarity and treatment in reference centers have proven their usefulness as well.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12123105