Ischemic Brain Injury: Involvement of Lipids in the Pathophysiology of Stroke and Therapeutic Strategies

Stroke is a devastating neurological disorder that is characterized by the sudden disruption of blood flow to the brain. Lipids are essential components of brain structure and function and play pivotal roles in stroke pathophysiology. Dysregulation of lipid signaling pathways modulates key cellular...

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Bibliographic Details
Published in:Antioxidants 2024-05, Vol.13 (6), p.634
Main Authors: Bernoud-Hubac, Nathalie, Lo Van, Amanda, Lazar, Adina-Nicoleta, Lagarde, Michel
Format: Article
Language:English
Subjects:
Animal models
Antioxidants
Apoptosis
Blood clots
Blood flow
Blood pressure
Blood vessels
brain
Brain injury
Cell culture
Cerebral blood flow
Cytochrome
Disability
Fatty acids
Free radicals
Functional anatomy
Hydrogen peroxide
Hypoxia
Ischemia
ischemic stroke
Lipids
Metabolism
Mortality
Neuroprotection
Nutrients
Oxidative stress
Pathogenesis
Pathophysiology
Permeability
Polyunsaturated fatty acids
Prevention
Review
Stroke
Structure-function relationships
Substance abuse treatment
therapeutic strategies
Traumatic brain injury
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Summary:Stroke is a devastating neurological disorder that is characterized by the sudden disruption of blood flow to the brain. Lipids are essential components of brain structure and function and play pivotal roles in stroke pathophysiology. Dysregulation of lipid signaling pathways modulates key cellular processes such as apoptosis, inflammation, and oxidative stress, exacerbating ischemic brain injury. In the present review, we summarize the roles of lipids in stroke pathology in different models (cell cultures, animal, and human studies). Additionally, the potential of lipids, especially polyunsaturated fatty acids, to promote neuroprotection and their use as biomarkers in stroke are discussed.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox13060634