Structural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition

Centrins are a family of small, EF hand-containing proteins that are found in all eukaryotes and are often complexed with centrosome-related structures. Since their discovery, centrins have attracted increasing interest due to their multiple, diverse cellular functions. Centrins are similar to calmo...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-11, Vol.22 (22), p.12173
Main Authors: Pedretti, Marco, Bombardi, Luca, Conter, Carolina, Favretto, Filippo, Dominici, Paola, Astegno, Alessandra
Format: Article
Language:English
Subjects:
Amino acids
Binding sites
Calcium - chemistry
Calcium - metabolism
Calcium ions
calcium signaling
Calcium signalling
Calcium-binding protein
Calcium-Binding Proteins - chemistry
Calcium-Binding Proteins - metabolism
Calcium-Binding Proteins - physiology
Calmodulin
Cell Cycle Proteins - metabolism
Cellular structure
centrin
Centrosome - metabolism
DNA Repair
EF Hand Motifs
EF-hand
Eukaryotes
Genes
Hands
Humans
Isoforms
Nuclear Proteins - metabolism
Phylogenetics
Protein Binding
protein interaction
Proteins
Review
RNA, Messenger - metabolism
Signal transduction
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Summary:Centrins are a family of small, EF hand-containing proteins that are found in all eukaryotes and are often complexed with centrosome-related structures. Since their discovery, centrins have attracted increasing interest due to their multiple, diverse cellular functions. Centrins are similar to calmodulin (CaM) in size, structure and domain organization, although in contrast to CaM, the majority of centrins possess at least one calcium (Ca ) binding site that is non-functional, thus displaying large variance in Ca sensing abilities that could support their functional versatility. In this review, we summarize current knowledge on centrins from both biophysical and structural perspectives with an emphasis on centrin-target interactions. In-depth analysis of the Ca sensing properties of centrins and structures of centrins complexed with target proteins can provide useful insight into the mechanisms of the different functions of centrins and how these proteins contribute to the complexity of the Ca signaling cascade. Moreover, it can help to better understand the functional redundancy of centrin isoforms and centrin-binding proteins.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222212173