Spontaneous Remission in an Older Patient with Relapsed FLT3 ITD Mutant AML

Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized by FLT3 internal tandem duplication (FLT3 ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short overall survival in the absence of transplantat...

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Bibliographic Details
Published in:Case reports in hematology 2016-01, Vol.2016 (2016), p.1-7
Main Authors: Wang, Eunice S., Starostik, Petr, Deeb, George, Evans, Andrew, Mendler, Jason H., Vachhani, Pankit, Wallace, Paul K.
Format: Article
Language:English
Subjects:
Biopsy
Blood
Bone marrow
Cancer
Cancer therapies
Case Report
Chemotherapy
Colleges & universities
Cytogenetics
Drug dosages
Family medical history
Immune system
Laboratories
Leukemia
Medical prognosis
Medicine
Mutation
Pathology
Patients
Stem cells
Transplants & implants
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Description
Summary:Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized by FLT3 internal tandem duplication (FLT3 ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short overall survival in the absence of transplantation. We report here the first case of SR of FLT3 ITD mutant AML in the literature. Our patient was an elderly woman with relapsed NPM1 and FLT3 ITD mutant AML whose disease underwent SR for a brief duration without precipitating cause. We review the potential immune mechanisms underlying SR in AML and discuss the implications for novel immunotherapeutic approaches for FLT3 mutant AML.
ISSN:2090-6560
2090-6579
DOI:10.1155/2016/1259759