Sublingual Delivery of Astaxanthin through a Novel Ascorbyl Palmitate-Based Nanoemulsion: Preliminary Data

Astaxanthin is a carotenoid extracted from several seaweeds with ascertained therapeutic activity. With specific reference, astaxanthin is widely used in clinical practice to improve ocular tissue health and skin protection from UV ray damages. Despite its well-documented pleiotropic actions and dem...

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Bibliographic Details
Published in:Marine drugs 2019-08, Vol.17 (9), p.508
Main Authors: Fratter, Andrea, Biagi, Damiano, Cicero, Arrigo F G
Format: Article
Language:English
Subjects:
Algae
ascorbyl palmitate
Astaxanthin
Bioavailability
Biological Availability
Carotenoids
Clinical trials
Emulsions
Emulsions - chemistry
Experiments
Flow velocity
Fluids
Franz cell
Functional foods & nutraceuticals
Humans
Hydrophobic and Hydrophilic Interactions
Hydrophobicity
nanoemulsion
Nanoemulsions
Nanoparticles - chemistry
Oxidative stress
Palmitates - chemistry
Palmitic acid
Permeability
Pharmaceuticals
Physiology
Preliminary Data
Raw materials
Seaweed - chemistry
Seaweeds
Solubility - drug effects
sublingual delivery
Thermal stress
Xanthophylls - administration & dosage
Xanthophylls - chemistry
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Summary:Astaxanthin is a carotenoid extracted from several seaweeds with ascertained therapeutic activity. With specific reference, astaxanthin is widely used in clinical practice to improve ocular tissue health and skin protection from UV ray damages. Despite its well-documented pleiotropic actions and demonstrated clinical efficacy, its bioavailability in humans is low and limited because of its hydrophobicity and poor dissolution in enteric fluids. Furthermore, astaxanthin is very unstable molecule and very sensitive to light exposure and thermal stress. Taken together, these pharmacological and chemical-physical features strongly limit pharmaceutical and nutraceutical development of astaxanthin-based products and as a consequence its full clinical usage. This work describes the preliminary in vitro investigation of sublingual absorption of astaxanthin through a novel ascorbyl palmitate (ASP) based nanoemulsion.
ISSN:1660-3397
1660-3397
DOI:10.3390/md17090508