miR-34a and miR-21 as biomarkers in evaluating the response of chemo-radiotherapy in Egyptian breast cancer patients

MiRNA-21 (miR-21) promotes the initiation and progression of tumor by initiating cell cycle differentiation, while miR-34a induces apoptosis through activating the tumor-suppressor gene p53, and by repressing the anti-apoptotic protein, B-cell lymphoma 2 (Bcl2). To investigate if the expression fold...

Full description

Saved in:
Bibliographic Details
Published in:Journal of radiation research and applied sciences 2022-09, Vol.15 (3), p.285-292
Main Authors: Shaban, Nadia Z., Ibrahim, Nashwa K., Saada, Helen N., El-Rashidy, Fatma H., Shaaban, HebatAllah M., Farrag, Mostafa A., ElDebaiky, Khaled, Kodous, Ahmad S.
Format: Article
Language:English
Subjects:
Bcl-2
BRCA1 BRCA2
Chemo-radiotherapy
Female
miR-21
miR-34a
P53 breast cancer
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:MiRNA-21 (miR-21) promotes the initiation and progression of tumor by initiating cell cycle differentiation, while miR-34a induces apoptosis through activating the tumor-suppressor gene p53, and by repressing the anti-apoptotic protein, B-cell lymphoma 2 (Bcl2). To investigate if the expression folds change of circulating miR-21 and miR-34a could be a potential marker to evaluate the response of female breast cancer (BC) patients to the chemo-radiotherapy treatment. and Methods: The study included 159 BC patients and 58 healthy females. Among patients’ 56 were Luminal A, 41 Luminal B, 15 Her-2/neu and 47 Basal like. Regarding stages, 118 BC patient were stage II, 12 stage I, and 29 stage III. Data of miR-21 and miR-34a were correlated with Bcl2, the breast cancer susceptibility genes BRCA1, and BRCA2, and p53. The expression of miR-21 is upregulated (p 
ISSN:1687-8507
1687-8507
DOI:10.1016/j.jrras.2022.08.001