Coexistence of bone and vascular disturbances in patients with endogenous glucocorticoid excess

Bone and vascular diseases are considered to share pathogenic mechanisms. Excess glucocorticoids, key regulators of cardiovascular and metabolic homeostasis, may promote both diseases simultaneously. We used endogenous Cushing's syndrome (CS) to investigate whether glucocorticoid excess underli...

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Bibliographic Details
Published in:Bone Reports 2022-12, Vol.17, p.101610-101610, Article 101610
Main Authors: Yano, Chieko, Yokomoto-Umakoshi, Maki, Fujita, Masamichi, Umakoshi, Hironobu, Yano, Seiichi, Iwahashi, Norifusa, Katsuhara, Shunsuke, Kaneko, Hiroki, Ogata, Masatoshi, Fukumoto, Tazuru, Terada, Eriko, Matsuda, Yayoi, Sakamoto, Ryuichi, Ogawa, Yoshihiro
Format: Article
Language:English
Subjects:
Atherosclerosis
Bone
Endogenous Cushing's syndrome
Full Length
Glucocorticoid
Osteoporosis
Vascular
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Summary:Bone and vascular diseases are considered to share pathogenic mechanisms. Excess glucocorticoids, key regulators of cardiovascular and metabolic homeostasis, may promote both diseases simultaneously. We used endogenous Cushing's syndrome (CS) to investigate whether glucocorticoid excess underlies coexisting bone and vascular diseases. We included 194 patients with adrenal tumors (ATs): autonomous cortisol secretion (ACS, n = 97) and non-functional AT (n = 97). ACS was further classified into overt CS (n = 17) and subclinical CS (SCS, n = 80). Arterial stiffness was defined as a brachial-ankle pulse wave velocity (baPWV) ≥ 1800 cm/s. Patients with ACS had higher coexistence rates of vertebral fracture and arterial stiffness (23 % vs. 2 %; p 
ISSN:2352-1872
2352-1872
DOI:10.1016/j.bonr.2022.101610