Circular RNAs: new biomarkers of chemoresistance in cancer

Chemotherapeutics are validated conventional treatments for patients with advanced cancer. However, with continual application of chemotherapeutics, chemoresistance, which is often predictive of poor prognosis, has gradually become a concern in recent years. Circular RNAs (circRNAs), a class of endo...

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Published in:Cancer biology & medicine 2021-05, Vol.18 (2), p.421-436
Main Authors: Wang, Jiaqi, Zhang, Yi, Liu, Lianyu, Yang, Ting, Song, Jun
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Language:English
Subjects:
cancer
chemoresistance
circular rna
drug resistance
Review
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creator Wang, Jiaqi
Zhang, Yi
Liu, Lianyu
Yang, Ting
Song, Jun
description Chemotherapeutics are validated conventional treatments for patients with advanced cancer. However, with continual application of chemotherapeutics, chemoresistance, which is often predictive of poor prognosis, has gradually become a concern in recent years. Circular RNAs (circRNAs), a class of endogenous noncoding RNAs (ncRNAs) with a closed-loop structure, have been reported to be notable targets and markers for the prognosis, diagnosis, and treatment of many diseases, particularly cancer. Although dozens of studies have shown that circRNAs play major roles in drug-resistance activity in tumors, the mechanisms by which circRNAs affect chemoresistance have yet to be explored. In this review, we describe the detailed mechanisms of circRNAs and chemotherapeutics in various cancers and summarize potential therapeutic targets for drug-resistant tumors.
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subjects cancer
chemoresistance
circular rna
drug resistance
Review
title Circular RNAs: new biomarkers of chemoresistance in cancer
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