Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection

Streptococcus pyogenes (also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, there are only a few reports on pleural empyema caused by GAS i...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in pediatrics 2018-01, Vol.2018 (2018), p.1-4
Main Authors: Ochi, Fumihiro, Ishii, Eiichi, Nagai, Kozo, Moritani, Tomozo, Tauchi, Hisamichi, Miura, Hiromitsu, Jogamoto, Toshihiro
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Bacterial infections
Biomarkers
Blood
Case Report
Case reports
Cytokines
Disease susceptibility
Empyema
Family medical history
Fever
Immunology
Infectious diseases
Influenza
Lymphocytes
Medical colleges
Neutrophils
Pathogenesis
Pediatrics
Pneumonia
Proteins
Sepsis
Septic shock
Streptococcus infections
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Streptococcus pyogenes (also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, there are only a few reports on pleural empyema caused by GAS in children. Here, we report the case of a 4-year-old boy who presented with pleural empyema due to GAS after influenza A virus infection. With intravenous antibiotic administration and continuous chest-tube drainage, followed by video-assisted thoracoscopic surgery, his condition improved. During the clinical course, cytokines induced in response to the influenza virus, especially IL-1β and IL-10, were elevated 1 week after influenza A infection, but these decreased as the symptoms improved. Reportedly, the IL-10 production increases during influenza virus-bacteria superinfection. These observations suggest that the immunological mechanisms induced by the influenza virus can play an important role in influencing the susceptibility to secondary bacterial infections, such as GAS, in children.
ISSN:2090-6803
2090-6811
DOI:10.1155/2018/4509847