Association of serum pleiotrophin levels with acute coronary syndrome

• Published in: International journal of the cardiovascular academy 2022-07, Vol.8 (3), p.78-82
• Main Authors: Basyigit, Funda, Karayigit, Orhan, Nurkoc, Serdar, Duyuler, Serkan, Duyuler, Pinar
• Format: Article
• Language: English
• Subjects: acutecoronary syndrome; angiogenesis; pleiotrophin
• ISSN: 2405-8181; 2405-819X
• DOI: 10.4103/ijca.ijca_11_22

Background and Aim: Pleiotrophin (PTN) is known as a multifunctional cytokine and a neurite outgrowth-promoting factor and appears as an angiogenic response to numerous processes such as ischemic injury affecting a region of the heart and the brain. We evaluated the serum concentration of PTN in clients with acute coronary syndrome (ACS), besides assessing the clients with no visible stenosis (NVS) in elective invasive coronary angiography (ICA). Materials and Methods: Through conducting a prospective research, we compared 110 consecutive patients with ACS referred for ICA with 47 stable patients with NVS. Results: We determined that ACS group had higher PTN levels than NVS group (244.94 ± 89.09 vs. 199.46 ± 70.71, P < 0.001). Based on the multivariate analysis, besides older age, smoking, and white blood cell, PTN ≥207.66 ng/ml remained independently associated with ACS. Conclusion: The serum concentration of PTN in clients was determined to have an association with ACS. The potential diagnostic and prognostic impact of PTN in ischemic heart disease may deserve to be further evaluated. PTN may also be studied as an angiogenic therapeutic factor in patients with ACS in additional studies.