Dissemination and genome characterization of a human adenovirus F41 in a patient with B-Cell lymphoma

Adenovirus (HAdV) F41 is a common cause of gastroenteritis and has rarely been reported associated with disseminated disease. In this report, an adult patient with a history of ulcerative colitis, cryptogenic cirrhosis, stage III adenocarcinoma, high-grade diffuse large B-cell lymphoma on chemothera...

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Bibliographic Details
Published in:Virology journal 2023-07, Vol.20 (1), p.141-141, Article 141
Main Authors: Fall, Amary, Campodónico, Victoria L, Howard, Craig, Gallagher, Nicholas, Bailey, Gabrielle, Kajon, Adriana E, Mostafa, Heba H
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenoviridae - genetics
Adenoviridae Infections
Adenovirus F41
Adenovirus Infections, Human
Adenoviruses
Adenoviruses, Human - genetics
Adult
Antiviral agents
B-cell lymphoma
Blood platelets
Bone marrow
Cancer
Care and treatment
Case Report
Chemotherapy
Cirrhosis
Control
Diagnosis
Disease
Dissemination
Dosage and administration
Epidemics
Epstein-Barr virus
Gastroenteritis
Genetic aspects
Genome characterization
Genomes
Genomics
Health aspects
Hepatitis
Humans
Hypotension
Identification and classification
Immunocompetence
Infection
Infections
Kidneys
Leukemia
Lymphocytes B
Lymphoma
Lymphoma, B-Cell - complications
Lymphomas
Male
Non-Hodgkin's lymphomas
Ostomy
Patient outcomes
Patients
Pediatrics
Phosphatase
Phylogenetics
Plasma
Stem cell transplantation
Thrombocytopenia
Ulcerative colitis
Urine
Vincristine
Whole genome sequencing
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Summary:Adenovirus (HAdV) F41 is a common cause of gastroenteritis and has rarely been reported associated with disseminated disease. In this report, an adult patient with a history of ulcerative colitis, cryptogenic cirrhosis, stage III adenocarcinoma, high-grade diffuse large B-cell lymphoma on chemotherapy was diagnosed with disseminated adenovirus infection. HAdV DNA was quantified in stool, plasma, and urine with viral loads of 7, 4, and 3 log10 copies/mL, respectively. The patient's course was rapidly progressive and he passed away 2 days after initiation of antiviral therapy. The patient's infecting virus was characterized as HAdV-F41 by whole genome sequencing.
ISSN:1743-422X
1743-422X
DOI:10.1186/s12985-023-02101-3