Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes

Background. The study aimed to assess whether women with prior gestational diabetes (pGDM), despite maintenance of normal glucose tolerance (NGT) five years after delivery, display metabolic disturbances compared to healthy controls. Methods. 45 pGDM with NGT were compared to 18 women without a hist...

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Bibliographic Details
Published in:International Journal of Endocrinology 2015-01, Vol.2015 (2015), p.715-721-078
Main Authors: Winhofer, Yvonne, Tura, Andrea, Thomas, Anita, Prikoszovich, Thomas, Winzer, Christine, Pacini, Giovanni, Luger, Anton, Kautzky-Willer, Alexandra
Format: Article
Language:English
Subjects:
Body mass index
Cardiovascular diseases
Catheters
Cholesterol
Chromium
Chronic illnesses
Complications and side effects
Diabetes in pregnancy
Endocrinology
Fasting
Gestational diabetes
Glucagon
Glucose
Glucose intolerance
Insulin resistance
Menstruation
Metabolism
Peptides
Pregnancy
Prognosis
Risk factors
Veins & arteries
Womens health
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Summary:Background. The study aimed to assess whether women with prior gestational diabetes (pGDM), despite maintenance of normal glucose tolerance (NGT) five years after delivery, display metabolic disturbances compared to healthy controls. Methods. 45 pGDM with NGT were compared to 18 women without a history of GDM (CON), matched for age (37.0 ± 4.1 versus 35.2 ± 5.3, P=ns) and BMI (24.3 ± 3.1 versus 23.3 ± 3.3, P=ns). Metabolic parameters were derived from oral and intravenous glucose tolerance tests; furthermore lipid profile, C-reactive protein (CRP), adiponectin, leptin, and glucagon were assessed. Results. Five years postpartum, pGDM had increased glucose concentrations during the OGTT (AUC: 1.12 ± 0.15 versus 1.0 ± 0.12 mol/L * min, P=0.003) and insulin sensitivity was decreased compared to CON (OGIS: 467.2 ± 64.1 versus 510.6 ± 53.1 mL/min * m2, P=0.01). pGDM had lower adiponectin (8.1 ± 2.6 versus 12.6 ± 5.3, P
ISSN:1687-8337
1687-8345
DOI:10.1155/2015/342938