HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma

Background. Ameloblastoma (AMB) is a benign odontogenic tumour, with an aggressive local behaviour and a high rate of recurrence. Previous studies have demonstrated that hypoxia-induced factor alpha 1 (HIF-1α) and activated caspase-3 contribute to tumour invasiveness and cytogenesis in ameloblastoma...

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Bibliographic Details
Published in:International journal of dentistry 2021, Vol.2021, p.3060375-10
Main Authors: Valladares, Katherine Julissa Palma, Balbinot, Karolyny Martins, Lopes de Moraes, Antonia Taiane, Kataoka, Maria Sueli da Silva, Ramos, Aline Maria Pereira Cruz, Ramos, Rommel Thiago Jucá, da Silva, Artur Luiz da Costa, Mesquita, Ricardo Alves, Normando, David, Alves Júnior, Sérgio de Melo, Pinheiro, João de Jesus Viana
Format: Article
Language:English
Subjects:
Ameloblastoma
Antibodies
Apoptosis
Bax protein
Bcl-2 protein
Binding sites
BNIP3 protein
Caspase-3
Cloning
Cytoplasm
Gene expression
Genetic analysis
Hypoxia
Hypoxia-inducible factor 1a
Invasiveness
Odontogenic tumors
p53 Protein
Proteins
Signal transduction
Transcriptomics
Tumorigenesis
Tumors
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Summary:Background. Ameloblastoma (AMB) is a benign odontogenic tumour, with an aggressive local behaviour and a high rate of recurrence. Previous studies have demonstrated that hypoxia-induced factor alpha 1 (HIF-1α) and activated caspase-3 contribute to tumour invasiveness and cytogenesis in ameloblastoma. Hypoxia increases HIF-1α levels, which triggers a number of signalling pathways. This paper aimed to present data in the study of hypoxia-activated signalling pathways that modulate proapoptotic and antiapoptotic events in AMB. Methods. Twenty cases of AMB and ten cases of dental follicle (DF) were used to analyse the immunoexpression of HIF-1α, p53, BNIP3, Bcl-2, IAP-2, GLUT1, and Bax. To contribute to the study, an analysis of expression and genetic interaction was performed using the cell line AME-1. Results. AMB and DF expressed the studied proteins. These proteins showed significantly greater immunoexpression in AMB compared with the DF (p
ISSN:1687-8728
1687-8736
DOI:10.1155/2021/3060375