Phagocytic Integrins: Activation and Signaling

Phagocytic integrins are endowed with the ability to engulf and dispose of particles of different natures. Evolutionarily conserved from worms to humans, they are involved in pathogen elimination and apoptotic and tumoral cell clearance. Research in the field of integrin-mediated phagocytosis has sh...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2020-04, Vol.11, p.738-738
Main Authors: Torres-Gomez, Alvaro, Cabañas, Carlos, Lafuente, Esther M
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - physiology
Animals
Apoptosis
complement
CR3
Humans
Immunology
Integrin alphaXbeta2 - physiology
integrins
Integrins - chemistry
Integrins - physiology
Mac-1
Macrophage-1 Antigen - physiology
Membrane Proteins - physiology
phagocytosis
Phagocytosis - physiology
Protein-Tyrosine Kinases - physiology
rap1 GTP-Binding Proteins - physiology
Signal Transduction - physiology
signaling
Talin - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phagocytic integrins are endowed with the ability to engulf and dispose of particles of different natures. Evolutionarily conserved from worms to humans, they are involved in pathogen elimination and apoptotic and tumoral cell clearance. Research in the field of integrin-mediated phagocytosis has shed light on the molecular events controlling integrin activation and their effector functions. However, there are still some aspects of the regulation of the phagocytic process that need to be clarified. Here, we have revised the molecular events controlling phagocytic integrin activation and the downstream signaling driving particle engulfment, and we have focused particularly on α β /CR3, α β /CR4, and a brief mention of α β /α β integrins.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.00738