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Phagocytic Integrins: Activation and Signaling
Phagocytic integrins are endowed with the ability to engulf and dispose of particles of different natures. Evolutionarily conserved from worms to humans, they are involved in pathogen elimination and apoptotic and tumoral cell clearance. Research in the field of integrin-mediated phagocytosis has sh...
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| Published in: | Frontiers in immunology 2020-04, Vol.11, p.738-738 |
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| Language: | English |
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| container_title | Frontiers in immunology |
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| creator | Torres-Gomez, Alvaro Cabañas, Carlos Lafuente, Esther M |
| description | Phagocytic integrins are endowed with the ability to engulf and dispose of particles of different natures. Evolutionarily conserved from worms to humans, they are involved in pathogen elimination and apoptotic and tumoral cell clearance. Research in the field of integrin-mediated phagocytosis has shed light on the molecular events controlling integrin activation and their effector functions. However, there are still some aspects of the regulation of the phagocytic process that need to be clarified. Here, we have revised the molecular events controlling phagocytic integrin activation and the downstream signaling driving particle engulfment, and we have focused particularly on α
β
/CR3, α
β
/CR4, and a brief mention of α
β
/α
β
integrins. |
| doi_str_mv | 10.3389/fimmu.2020.00738 |
| format | article |
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β
/CR3, α
β
/CR4, and a brief mention of α
β
/α
β
integrins.</description><identifier>ISSN: 1664-3224</identifier><identifier>EISSN: 1664-3224</identifier><identifier>DOI: 10.3389/fimmu.2020.00738</identifier><identifier>PMID: 32425937</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>Adaptor Proteins, Signal Transducing - physiology ; Animals ; Apoptosis ; complement ; CR3 ; Humans ; Immunology ; Integrin alphaXbeta2 - physiology ; integrins ; Integrins - chemistry ; Integrins - physiology ; Mac-1 ; Macrophage-1 Antigen - physiology ; Membrane Proteins - physiology ; phagocytosis ; Phagocytosis - physiology ; Protein-Tyrosine Kinases - physiology ; rap1 GTP-Binding Proteins - physiology ; Signal Transduction - physiology ; signaling ; Talin - physiology</subject><ispartof>Frontiers in immunology, 2020-04, Vol.11, p.738-738</ispartof><rights>Copyright © 2020 Torres-Gomez, Cabañas and Lafuente.</rights><rights>Copyright © 2020 Torres-Gomez, Cabañas and Lafuente. 2020 Torres-Gomez, Cabañas and Lafuente</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-6539adbf4a997f36e026d3c22661089ad6131fa1b1fb303c8f0541b51685efbf3</citedby><cites>FETCH-LOGICAL-c528t-6539adbf4a997f36e026d3c22661089ad6131fa1b1fb303c8f0541b51685efbf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203660/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203660/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32425937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torres-Gomez, Alvaro</creatorcontrib><creatorcontrib>Cabañas, Carlos</creatorcontrib><creatorcontrib>Lafuente, Esther M</creatorcontrib><title>Phagocytic Integrins: Activation and Signaling</title><title>Frontiers in immunology</title><addtitle>Front Immunol</addtitle><description>Phagocytic integrins are endowed with the ability to engulf and dispose of particles of different natures. Evolutionarily conserved from worms to humans, they are involved in pathogen elimination and apoptotic and tumoral cell clearance. Research in the field of integrin-mediated phagocytosis has shed light on the molecular events controlling integrin activation and their effector functions. However, there are still some aspects of the regulation of the phagocytic process that need to be clarified. Here, we have revised the molecular events controlling phagocytic integrin activation and the downstream signaling driving particle engulfment, and we have focused particularly on α
β
/CR3, α
β
/CR4, and a brief mention of α
β
/α
β
integrins.</description><subject>Adaptor Proteins, Signal Transducing - physiology</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>complement</subject><subject>CR3</subject><subject>Humans</subject><subject>Immunology</subject><subject>Integrin alphaXbeta2 - physiology</subject><subject>integrins</subject><subject>Integrins - chemistry</subject><subject>Integrins - physiology</subject><subject>Mac-1</subject><subject>Macrophage-1 Antigen - physiology</subject><subject>Membrane Proteins - physiology</subject><subject>phagocytosis</subject><subject>Phagocytosis - physiology</subject><subject>Protein-Tyrosine Kinases - physiology</subject><subject>rap1 GTP-Binding Proteins - physiology</subject><subject>Signal Transduction - physiology</subject><subject>signaling</subject><subject>Talin - physiology</subject><issn>1664-3224</issn><issn>1664-3224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkUtLxDAQgIMoKurdk-zRy65JJsmmHgQRHwuCgnoO0zSpkTbRpCv47627KprLhHl8M_ARcsjoDEBXJz70_XLGKaczSuegN8guU0pMgXOx-ee_Qw5KeaHjExUAyG2yA1xwWcF8l8zun7FN9mMIdrKIg2tziOV0cm6H8I5DSHGCsZk8hDZiF2K7T7Y8dsUdfMc98nR1-XhxM729u15cnN9OreR6mCoJFTa1F1hVcw_KUa4asJwrxageS4oB88hq5mugYLWnUrBaMqWl87WHPbJYc5uEL-Y1hx7zh0kYzCqRcmswjzd3zkjrdFOJSjTYCOZcreW4r-YarZAO2cg6W7Nel3XvGuvikLH7B_1fieHZtOndzDkFpegIOP4G5PS2dGUwfSjWdR1Gl5bFcEGFElxIMbbSdavNqZTs_O8aRs2XNbOyZr6smZW1ceTo73m_Az-O4BNbjZOf</recordid><startdate>20200430</startdate><enddate>20200430</enddate><creator>Torres-Gomez, Alvaro</creator><creator>Cabañas, Carlos</creator><creator>Lafuente, Esther M</creator><general>Frontiers Media S.A</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200430</creationdate><title>Phagocytic Integrins: Activation and Signaling</title><author>Torres-Gomez, Alvaro ; Cabañas, Carlos ; Lafuente, Esther M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-6539adbf4a997f36e026d3c22661089ad6131fa1b1fb303c8f0541b51685efbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adaptor Proteins, Signal Transducing - physiology</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>complement</topic><topic>CR3</topic><topic>Humans</topic><topic>Immunology</topic><topic>Integrin alphaXbeta2 - physiology</topic><topic>integrins</topic><topic>Integrins - chemistry</topic><topic>Integrins - physiology</topic><topic>Mac-1</topic><topic>Macrophage-1 Antigen - physiology</topic><topic>Membrane Proteins - physiology</topic><topic>phagocytosis</topic><topic>Phagocytosis - physiology</topic><topic>Protein-Tyrosine Kinases - physiology</topic><topic>rap1 GTP-Binding Proteins - physiology</topic><topic>Signal Transduction - physiology</topic><topic>signaling</topic><topic>Talin - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torres-Gomez, Alvaro</creatorcontrib><creatorcontrib>Cabañas, Carlos</creatorcontrib><creatorcontrib>Lafuente, Esther M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torres-Gomez, Alvaro</au><au>Cabañas, Carlos</au><au>Lafuente, Esther M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phagocytic Integrins: Activation and Signaling</atitle><jtitle>Frontiers in immunology</jtitle><addtitle>Front Immunol</addtitle><date>2020-04-30</date><risdate>2020</risdate><volume>11</volume><spage>738</spage><epage>738</epage><pages>738-738</pages><issn>1664-3224</issn><eissn>1664-3224</eissn><abstract>Phagocytic integrins are endowed with the ability to engulf and dispose of particles of different natures. Evolutionarily conserved from worms to humans, they are involved in pathogen elimination and apoptotic and tumoral cell clearance. Research in the field of integrin-mediated phagocytosis has shed light on the molecular events controlling integrin activation and their effector functions. However, there are still some aspects of the regulation of the phagocytic process that need to be clarified. Here, we have revised the molecular events controlling phagocytic integrin activation and the downstream signaling driving particle engulfment, and we have focused particularly on α
β
/CR3, α
β
/CR4, and a brief mention of α
β
/α
β
integrins.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>32425937</pmid><doi>10.3389/fimmu.2020.00738</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing - physiology Animals Apoptosis complement CR3 Humans Immunology Integrin alphaXbeta2 - physiology integrins Integrins - chemistry Integrins - physiology Mac-1 Macrophage-1 Antigen - physiology Membrane Proteins - physiology phagocytosis Phagocytosis - physiology Protein-Tyrosine Kinases - physiology rap1 GTP-Binding Proteins - physiology Signal Transduction - physiology signaling Talin - physiology |
| title | Phagocytic Integrins: Activation and Signaling |
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