Combined Effects of Vitamin D Status, Renal Function and Age on Serum Parathyroid Hormone Levels

Vitamin D status and renal function are well-known independent predictors of serum parathyroid hormone (PTH) levels. We aimed to describe the combined effects of 25-hydroxy vitamin D (25(OH)D), glomerular filtration rate (GFR) and age on serum PTH levels across the whole clinical spectrum. We retrie...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2021-04, Vol.12, p.657991-657991
Main Authors: Niculescu, Dan Alexandru, Deacu, Laura Georgiana, Caragheorgheopol, Andra, Popescu, Nicoleta, Ghemigian, Adina, Procopiuc, Camelia, Rosca, Roxana, Poiana, Catalina
Format: Article
Language:English
Subjects:
25-hydroxy vitamin D
Adolescent
Adult
age
Age Factors
Aged
Child
chronic kidney disease
Creatinine - blood
Endocrinology
Female
Glomerular Filtration Rate
Humans
Hyperparathyroidism - blood
Hyperparathyroidism - physiopathology
Hypoparathyroidism - blood
Hypoparathyroidism - physiopathology
Kidney - physiopathology
Male
Middle Aged
parathyroid hormone
Parathyroid Hormone - blood
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - physiopathology
Retrospective Studies
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:Vitamin D status and renal function are well-known independent predictors of serum parathyroid hormone (PTH) levels. We aimed to describe the combined effects of 25-hydroxy vitamin D (25(OH)D), glomerular filtration rate (GFR) and age on serum PTH levels across the whole clinical spectrum. We retrieved from our endocrinology center database all PTH measurement between 2012 and 2020 for which a simultaneous measurement of serum 25(OH)D, calcium and creatinine was available. Age, sex and diagnosis were available for all subjects. Intact PTH was measured using the same electrochemiluminescence assay. There were 6,444 adults and 701 children without a diagnosis of hyper- or hypoparathyroidism or abnormal serum calcium levels. In adults with 25(OH)D≥12 ng/mL multiple regression models showed that serum PTH was negatively correlated with both 25(OH)D and GFR. Regression (-0.68 and -1.59 vs. -0.45 and -0.22 respectively), partial correlation (-0.16 and -0.35 vs. -0.12 and -0.10 respectively) and determination coefficients (0.14 vs. 0.031) were higher in CKD than in normal renal function. In subjects with 25(OH)D
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2021.657991