Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials

The mushroom secretes biologically active compounds and proteins with benefits for human health. Most reported proteins from are tyrosinases and lectins. Lectins are of therapeutic or pharmaceutical interest. To date, only limited information is available on lectins and lectin-like proteins. No ther...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-05, Vol.25 (10), p.2368
Main Authors: Ismaya, Wangsa Tirta, Tjandrawinata, Raymond Rubianto, Rachmawati, Heni
Format: Article
Language:English
Subjects:
Agaricus - chemistry
Agaricus - genetics
Agaricus bisporus
anticancer
Basidiocarps
Bioactive compounds
biological active fraction
Biological activity
Breast cancer
Carbohydrates
Diet
Dietary minerals
Enzymes
Genome, Fungal - genetics
Genomes
Humans
Immune system
Immunoglobulins
immunomodulator
Lectins
Lectins - genetics
Lectins - therapeutic use
Mannose
Mannose-binding lectin
Mannose-Binding Lectin - chemistry
Mannose-Binding Lectin - genetics
Mannose-Binding Lectin - therapeutic use
Metabolites
Monophenol Monooxygenase - chemistry
Monophenol Monooxygenase - genetics
Mushrooms
Pharmaceuticals
Proteins
Review
sugar-binding proteins
therapeutic protein
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Description
Summary:The mushroom secretes biologically active compounds and proteins with benefits for human health. Most reported proteins from are tyrosinases and lectins. Lectins are of therapeutic or pharmaceutical interest. To date, only limited information is available on lectins and lectin-like proteins. No therapeutic products derived from lectin (ABL) are available on the market despite its extensive exploration. Recently, mannose-binding protein (Abmb) was discovered. Its discovery enriches the information and increases the interest in proteins with therapeutic potential from this mushroom. Furthermore, the genome reveals the possible occurrence of other lectins in this mushroom that may also have therapeutic potential. Most of these putative lectins belong to the same lectin groups as ABL and Abmb. Their relationship is discussed. Particular attention is addressed to ABL and Abmb, which have been explored for their potential in medicinal or pharmaceutical applications. ABL and Abmb have anti-proliferative activities toward cancer cells and a stimulatory effect on the immune system. Possible scenarios for their use in therapy and modification are also presented.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25102368