Effects of Compounds Isolated from Lindera erythrocarpa on Anti-Inflammatory and Anti-Neuroinflammatory Action in BV2 Microglia and RAW264.7 Macrophage

Lindera erythrocarpa contains various constituents such as cyclopentenedione-, flavonoid-, and chalcone-type components. In this study, a novel bi-linderone derivative and 17 known compounds were isolated from the leaves of L. erythrocarpa by using various chromatographic methods. The structures of...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-07, Vol.23 (13), p.7122
Main Authors: Yoon, Chi-Su, Lee, Hwan, Liu, Zhiming, Lee, Hyeong-Kyu, Lee, Dong-Sung
Format: Article
Language:English
Subjects:
Alzheimer's disease
anti-inflammation
anti-neuroinflammation
bi-linderone
Carbon
Chromatography
Cyclooxygenase-2
Flavonoids
Inflammation
Interleukin 6
Lindera
Lindera erythrocarpa
Lipopolysaccharides
Macrophages
Mass spectrometry
Mass spectroscopy
Microglia
Neurodegeneration
NF-κB protein
Nitric oxide
Nitric-oxide synthase
NMR
Nuclear magnetic resonance
Prostaglandin E2
Proteins
Toxicity
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:Lindera erythrocarpa contains various constituents such as cyclopentenedione-, flavonoid-, and chalcone-type components. In this study, a novel bi-linderone derivative and 17 known compounds were isolated from the leaves of L. erythrocarpa by using various chromatographic methods. The structures of the components were determined from nuclear magnetic resonance and mass spectrometry data. All isolated compounds were tested for anti-inflammatory and anti-neuroinflammatory activities in lipopolysaccharide (LPS)-induced BV2 and RAW264.7 cells. Some of these compounds showed anti-inflammatory effects by inhibiting the nitric oxide (NO) produced by LPS. In particular, linderaspirone A (16), bi-linderone (17) and novel compound demethoxy-bi-linderone (18) showed significant inhibitory effects on the production of prostaglandin E2 (PGE2), tumor necrosis factor-α, and interleukin-6. The three compounds also inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are pro-inflammatory proteins, and the activation of nuclear factor κB (NF-κB). Therefore, linderaspirone A (16), bi-linderone (17), and demethoxy-bi-linderone (18) isolated from the leaves of L. erythrocarpa have therapeutic potential in neuroinflammatory diseases.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23137122