PBN-PVT projections modulate negative affective states in mice

Long-lasting negative affections dampen enthusiasm for life, and dealing with negative affective states is essential for individual survival. The parabrachial nucleus (PBN) and thalamic paraventricular nucleus (PVT) are critical for modulating affective states in mice. However, the functional roles...

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Bibliographic Details
Published in:eLife 2022-02, Vol.11
Main Authors: Zhu, Ya-Bing, Wang, Yan, Hua, Xiao-Xiao, Xu, Ling, Liu, Ming-Zhe, Zhang, Rui, Liu, Peng-Fei, Li, Jin-Bao, Zhang, Ling, Mu, Di
Format: Article
Language:English
Subjects:
Affect (Psychology)
affective states
Animals
Anxiety
Aversion
Behavior
Emotional behavior
Hypothalamus
Lasers
Mice
Neurons
Neurons - physiology
Neuroscience
Pain perception
Parabrachial Nucleus
Paraventricular nucleus
Spinal cord
Synapses
Synaptogenesis
thalamic paraventricular nucleus
Thalamus
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Summary:Long-lasting negative affections dampen enthusiasm for life, and dealing with negative affective states is essential for individual survival. The parabrachial nucleus (PBN) and thalamic paraventricular nucleus (PVT) are critical for modulating affective states in mice. However, the functional roles of PBN-PVT projections in modulating affective states remain elusive. Here, we show that PBN neurons send dense projection fibers to the PVT and form direct excitatory synapses with PVT neurons. Activation of the PBN-PVT pathway induces robust behaviors associated with negative affective states without affecting nociceptive behaviors. Inhibition of the PBN-PVT pathway reduces aversion-like and fear-like behaviors. Furthermore, the PVT neurons innervated by the PBN are activated by aversive stimulation, and activation of PBN-PVT projections enhances the neuronal activity of PVT neurons in response to the aversive stimulus. Consistently, activation of PVT neurons that received PBN-PVT projections induces anxiety-like behaviors. Thus, our study indicates that PBN-PVT projections modulate negative affective states in mice.
ISSN:2050-084X
2050-084X
DOI:10.7554/ELIFE.68372