Apparent Insulin Deficiency in an Adult African Population With New-Onset Type 2 Diabetes

Identifying patients with new-onset type 2 diabetes who have insulin deficiency can aid in timely insulin replacement therapy. In this study, we measured fasting C-peptide concentration to assess endogenous insulin secretion and determine the prevalence and characteristics of patients with insulin d...

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Bibliographic Details
Published in:Frontiers in clinical diabetes and healthcare (online) 2022-07, Vol.3, p.944483-944483
Main Authors: Kibirige, Davis, Sekitoleko, Isaac, Balungi, Priscilla, Lumu, William, Nyirenda, Moffat J
Format: Article
Language:English
Subjects:
adult
Clinical Diabetes and Healthcare
insulin deficiency
newly diabetes mellitus
Sub-Sahara Africa
Uganda
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Summary:Identifying patients with new-onset type 2 diabetes who have insulin deficiency can aid in timely insulin replacement therapy. In this study, we measured fasting C-peptide concentration to assess endogenous insulin secretion and determine the prevalence and characteristics of patients with insulin deficiency in adult Ugandan patients with confirmed type 2 diabetes at presentation. Adult patients with new-onset diabetes were recruited from seven tertiary hospitals in Uganda. Participants who were positive for the three islet autoantibodies were excluded. Fasting C-peptide concentrations were measured in 494 adult patients, and insulin deficiency was defined as a fasting C-peptide concentration
ISSN:2673-6616
2673-6616
DOI:10.3389/fcdhc.2022.944483