LncRNA XIST promotes bladder cancer progression by modulating miR-129-5p/TNFSF10 axis

Background The differential expression, biological function, and ceRNA regulatory mechanism of lncRNA XIST in bladder cancer (BC) were investigated, and its clinical values for the early diagnosis of bladder cancer patients were elucidated. Methods qRT-PCR was employed to detect the expression patte...

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Bibliographic Details
Published in:Discover. Oncology 2024-03, Vol.15 (1), p.65-65, Article 65
Main Authors: Kong, Yu-Lin, Wang, Hui-Dan, Gao, Meng, Rong, Sheng-Zhong, Li, Xiao-Xia
Format: Article
Language:English
Subjects:
Binding sites
Bioinformatics
Biomarkers
Bladder cancer
Cancer Research
Cell growth
Chemotherapy
Genes
Genomes
Internal Medicine
Medicine
Medicine & Public Health
Metastasis
MicroRNAs
Molecular Medicine
Oncology
Pathogenesis
Radiation therapy
Radiotherapy
Statistical analysis
Surgical Oncology
Tumors
X chromosomes
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Summary:Background The differential expression, biological function, and ceRNA regulatory mechanism of lncRNA XIST in bladder cancer (BC) were investigated, and its clinical values for the early diagnosis of bladder cancer patients were elucidated. Methods qRT-PCR was employed to detect the expression patterns of lncRNA XIST, miR-129-5p and TNFSF10. The biological functions were measured by CCK8 assay, wound healing assay and transwell assay. Bioinformatics analysis and Dual-Luciferase reporter assay were employed to evaluate the interactions between the lncRNA XIST, miR-129-5p and TNFSF10. Results LncRNA XIST and TNFSF10 were highly expressed and miR-129-5p was low expressed ( P  
ISSN:2730-6011
2730-6011
DOI:10.1007/s12672-024-00910-8