Association between Dyslipidemia and Chronic Rhinosinusitis in a Korean Population

This study aims to assess the relationship between chronic rhinosinusitis (CRS) and dyslipidemia in a Korean population. The population aged 40 years or over was selected from the Korean National Health Insurance Service-National Health Screening Cohort. CRS was defined if patients were treated ≥2 t...

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Bibliographic Details
Published in:Diagnostics (Basel) 2020-12, Vol.11 (1), p.26
Main Authors: Wee, Jee Hye, Min, Chanyang, Park, Min Woo, Byun, Soo Hwan, Lee, Hyo-Jeong, Song, Chang Myeon, Park, Bumjung, Choi, Hyo Geun
Format: Article
Language:English
Subjects:
Age
Alcohol
Body mass index
Cholesterol
Codes
dyslipidemias
Health insurance
inflammation
Lipids
Medical screening
Metabolic syndrome
nasal polyps
Obesity
Patients
Population
population surveillance
sinusitis
Womens health
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Summary:This study aims to assess the relationship between chronic rhinosinusitis (CRS) and dyslipidemia in a Korean population. The population aged 40 years or over was selected from the Korean National Health Insurance Service-National Health Screening Cohort. CRS was defined if patients were treated ≥2 times with ICD-10 code (J32) and underwent head and neck computed tomography. Patients with CRS were classified as having nasal polyps (J33) or not. Dyslipidemia was defined if participants with the ICD-10 code (E78) were treated ≥2 times from 2002 to 2015. A total of 6163 patients with CRS were matched with 24,652 controls (1:4 ratio) for sex, age, income, and residence. The adjusted odds ratios (aORs) of a previous dyslipidemia in patients with CRS were analyzed by conditional logistic regression analysis, adjusted for confounding factors. The prevalence of dyslipidemia was significantly higher in participants with CRS (26.1%) than in the controls (20.6%) ( < 0.001). There was a significant positive association between CRS with/without nasal polyps and dyslipidemia (aOR = 1.36, 95%CI = 1.26-1.47, < 0.001). The association between CRS and dyslipidemia was stronger for CRS without nasal polyps (aOR = 1.42, 95% CI = 1.28-1.57, < 0.001) than for CRS with nasal polyps (aOR = 1.31, 95% CI = 1.17-1.47, < 0.001). All age and sex subgroups exhibited consistent results. A personal history of dyslipidemia was associated with risk of CRS regardless of total cholesterol and the use of statins.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics11010026