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Plasma serotonin level in left-sided colonic diverticulosis: A pilot study
Neurotransmitters might participate in the development of diverticular disease. We measured fasting and postprandial serotonin levels in colonic diverticulosis patients and healthy volunteers. We demonstrated significantly lower maximal concentrations of serotonin in patients than the controls (resp...
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Published in: | Central European journal of medicine 2012-10, Vol.7 (5), p.591-595 |
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description | Neurotransmitters might participate in the development of diverticular disease. We measured fasting and postprandial serotonin levels in colonic diverticulosis patients and healthy volunteers. We demonstrated significantly lower maximal concentrations of serotonin in patients than the controls (respectively 109.8±61.4 and 251.3±44.1 ng/ml, p |
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We measured fasting and postprandial serotonin levels in colonic diverticulosis patients and healthy volunteers. We demonstrated significantly lower maximal concentrations of serotonin in patients than the controls (respectively 109.8±61.4 and 251.3±44.1 ng/ml, p<0.001) as well as lower serotonin minimal values (respectively 38.4±21.8 and 124.6±41.4 ng/ml, p<0.001) and areas under time-course curves (respectively 288.8±139.8 and 739±167.4 ng/ml, p<0.001); significant difference between alternating pattern and normal bowel habit concerning fasting serotonin level, the hormone response to test meal (p=0.041) as well as minimal serotonin level (p=0.044). Bowel habit was also related to peak serotonin values following a test meal with 38.5 ng/ml in constipation, 139.5 ng/ml in diarrhea, 122.4 ng/ml in alternating pattern and 249 ng/ml in subjects with normal bowel habit (p=0.040) as well as AUC with 120.8 ng/ml in constipation, 416 ng/ml in diarrhea, 298 ng/ml in alternating pattern and 684 ng/ml in subjects with normal bowel habit (p=0.043). We demonstrated substantial differences in fasting serum serotonin levels as well as the hormone response to a test meal between colonic diverticulosis patients and healthy individuals, which seemed to be associated with abnormal bowel habits rather than presence of diverticula.</description><identifier>ISSN: 1895-1058</identifier><identifier>ISSN: 2391-5463</identifier><identifier>EISSN: 1644-3640</identifier><identifier>EISSN: 2391-5463</identifier><identifier>DOI: 10.2478/s11536-012-0041-9</identifier><language>eng</language><publisher>Heidelberg: SP Versita</publisher><subject>Biomedicine ; Colon ; Diverticulosis ; Internal Medicine ; Maternal and Child Health ; Medicine ; Medicine & Public Health ; Reproductive Medicine ; Research Article ; Serotonin ; Surgery</subject><ispartof>Central European journal of medicine, 2012-10, Vol.7 (5), p.591-595</ispartof><rights>Versita Warsaw and Springer-Verlag Berlin Heidelberg 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c432t-d7cc4c85a3c751b952d2632f24fca03e2cedb549fd6b657e5a3d3c5b10e0faef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.2478/s11536-012-0041-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.2478/s11536-012-0041-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41418,42487,51318,67030,68814</link.rule.ids></links><search><creatorcontrib>Neubauer, Katarzyna</creatorcontrib><creatorcontrib>Krzystek-Korpacka, Małgorzata</creatorcontrib><creatorcontrib>Paradowski, Leszek</creatorcontrib><title>Plasma serotonin level in left-sided colonic diverticulosis: A pilot study</title><title>Central European journal of medicine</title><addtitle>cent.eur.j.med</addtitle><description>Neurotransmitters might participate in the development of diverticular disease. We measured fasting and postprandial serotonin levels in colonic diverticulosis patients and healthy volunteers. We demonstrated significantly lower maximal concentrations of serotonin in patients than the controls (respectively 109.8±61.4 and 251.3±44.1 ng/ml, p<0.001) as well as lower serotonin minimal values (respectively 38.4±21.8 and 124.6±41.4 ng/ml, p<0.001) and areas under time-course curves (respectively 288.8±139.8 and 739±167.4 ng/ml, p<0.001); significant difference between alternating pattern and normal bowel habit concerning fasting serotonin level, the hormone response to test meal (p=0.041) as well as minimal serotonin level (p=0.044). Bowel habit was also related to peak serotonin values following a test meal with 38.5 ng/ml in constipation, 139.5 ng/ml in diarrhea, 122.4 ng/ml in alternating pattern and 249 ng/ml in subjects with normal bowel habit (p=0.040) as well as AUC with 120.8 ng/ml in constipation, 416 ng/ml in diarrhea, 298 ng/ml in alternating pattern and 684 ng/ml in subjects with normal bowel habit (p=0.043). We demonstrated substantial differences in fasting serum serotonin levels as well as the hormone response to a test meal between colonic diverticulosis patients and healthy individuals, which seemed to be associated with abnormal bowel habits rather than presence of diverticula.</description><subject>Biomedicine</subject><subject>Colon</subject><subject>Diverticulosis</subject><subject>Internal Medicine</subject><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Reproductive Medicine</subject><subject>Research Article</subject><subject>Serotonin</subject><subject>Surgery</subject><issn>1895-1058</issn><issn>2391-5463</issn><issn>1644-3640</issn><issn>2391-5463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqNUE1rGzEQXUICTdz-gN4Wclajb61yKBjTJC6B5JCehVYamTWK5Ui7Lv73lbOl9FLoaR4z72N4TfOZ4C-Uq-6mECKYRJhQhDEnSJ81l0Ryjpjk-LziTgtEsOg-NFelbDGWWOnusvn-HG15tW2BnMa0G3ZthAPE9h2EEZXBg29divXmWj8cII-Dm2IqQ7ltl-1-iGlsyzj548fmIthY4NPvuWh-3H17WT2gx6f79Wr5iBxndEReOcddJyxzSpBeC-qpZDRQHpzFDKgD3wuug5e9FAoq0TMneoIBBwuBLZr17OuT3Zp9Hl5tPppkB_O-SHlj7OnJCEZ41lvSScUE471QvWKqhnLGPCYBQ_W6nr32Ob1NUEazTVPe1fcNwVR3WjJNK4vMLJdTKRnCn1SCzal-M9dvav3mVL_RVfN11vy0cYTsYZOnYwV_B_xDq4TQpBrQ2aDUsN3mv5TsF499myg</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Neubauer, Katarzyna</creator><creator>Krzystek-Korpacka, Małgorzata</creator><creator>Paradowski, Leszek</creator><general>SP Versita</general><general>Versita</general><general>Walter de Gruyter GmbH</general><general>De Gruyter</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>DOA</scope></search><sort><creationdate>20121001</creationdate><title>Plasma serotonin level in left-sided colonic diverticulosis: A pilot study</title><author>Neubauer, Katarzyna ; 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We measured fasting and postprandial serotonin levels in colonic diverticulosis patients and healthy volunteers. We demonstrated significantly lower maximal concentrations of serotonin in patients than the controls (respectively 109.8±61.4 and 251.3±44.1 ng/ml, p<0.001) as well as lower serotonin minimal values (respectively 38.4±21.8 and 124.6±41.4 ng/ml, p<0.001) and areas under time-course curves (respectively 288.8±139.8 and 739±167.4 ng/ml, p<0.001); significant difference between alternating pattern and normal bowel habit concerning fasting serotonin level, the hormone response to test meal (p=0.041) as well as minimal serotonin level (p=0.044). Bowel habit was also related to peak serotonin values following a test meal with 38.5 ng/ml in constipation, 139.5 ng/ml in diarrhea, 122.4 ng/ml in alternating pattern and 249 ng/ml in subjects with normal bowel habit (p=0.040) as well as AUC with 120.8 ng/ml in constipation, 416 ng/ml in diarrhea, 298 ng/ml in alternating pattern and 684 ng/ml in subjects with normal bowel habit (p=0.043). We demonstrated substantial differences in fasting serum serotonin levels as well as the hormone response to a test meal between colonic diverticulosis patients and healthy individuals, which seemed to be associated with abnormal bowel habits rather than presence of diverticula.</abstract><cop>Heidelberg</cop><pub>SP Versita</pub><doi>10.2478/s11536-012-0041-9</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Biomedicine Colon Diverticulosis Internal Medicine Maternal and Child Health Medicine Medicine & Public Health Reproductive Medicine Research Article Serotonin Surgery |
title | Plasma serotonin level in left-sided colonic diverticulosis: A pilot study |
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