PEG-400 catalysed selective C-Se cross dehydrogenative coupling: An ultrasonication‐assisted green strategy

• Published in: Results in Chemistry 2023-01, Vol.5, p.100944, Article 100944
• Main Authors: Qadir, Mahpara, Yaseen, Aadil, Amin Shah, Wajaht
• Format: Article
• Language: English
• Subjects: C-Se bond formation; Cross Dehydrogenative Coupling; Green Protocol; PEG-400; Sonication; Transition metal free
• ISSN: 2211-7156; 2211-7156
• DOI: 10.1016/j.rechem.2023.100944

[Display omitted] Metal free selective C-Se cross dehydrogenative coupling strategy has been established. The disclosed protocol unites structurally complex molecular hybrids with phenylselenol to sp2 carbon with complete regioselectivity to foster novel phenylseleno-substituted hydrazonoindolin-2-one hybrids. The product was achieved via C-H activation path and was impossible without transition metal catalysts till date. Herein we have achieved unification via Cross dehydrogenative Coupling in PEG-400 with sonication synergistic effect which sets new and easy method to achieve such a difficult path through easy reaction route. The simple reaction setup with PEG-400, a green and inexpensive catalyst solvent system, sonication a green energy source, suitable reaction time, better product yield serves as a complete green compendium to achieve metal free C-Se coupling reaction. Hence the reported methodology will act as a base for designing routes for other important molecular hybrids using green synergy of sonication and PEG-400.