From Chilblains (Pernio) to Coeliac Disease-Should We Still Consider It Random?

Coeliac disease (CD) is a gluten-triggered, immune-mediated inflammatory disease occurring in genetically predisposed individuals, causing a variety of gastrointestinal and extraintestinal symptoms. The most common cutaneous association of CD is dermatitis herpetiformis, although recent reports have...

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Bibliographic Details
Published in:Children (Basel) 2022-12, Vol.9 (12), p.1972
Main Authors: Mašić, Mario, Močić Pavić, Ana, Gagro, Alenka, Balažin Vučetić, Ana, Ožanić Bulić, Suzana, Mišak, Zrinjka
Format: Article
Language:English
Subjects:
Alopecia
Antibodies
Autoimmune diseases
Baldness
Body mass index
Case Report
Celiac disease
coeliac disease
Cytoplasm
Dermatitis
Eating disorders
Endoscopy
Erythema
Fingers & toes
Gluten
gluten-free diet
Immunoglobulins
Laboratories
Medical research
Patients
Pediatrics
pernio
Physiological aspects
Polymorphism
Psoriasis
Serology
Skin
vasculitis
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Summary:Coeliac disease (CD) is a gluten-triggered, immune-mediated inflammatory disease occurring in genetically predisposed individuals, causing a variety of gastrointestinal and extraintestinal symptoms. The most common cutaneous association of CD is dermatitis herpetiformis, although recent reports have sought to link CD with other dermatological and autoimmune diseases. Chilblain, also called pernio, is usually a benign, superficial and localized inflammatory skin disorder that results from a maladaptive vascular response to non-freezing cold. We present a patient with pernio (chilblains) and newly diagnosed CD, with a significant intestinal lesion-total villous atrophy, as there are only two known cases of this feature associated with CD published in the literature. In the workup of chilblains (pernio) in children, an active case finding for coeliac disease should be conducted with coeliac-specific serology testing.
ISSN:2227-9067
2227-9067
DOI:10.3390/children9121972