Investigation of a Minocycline-Loaded Nanoemulgel for the Treatment of Acne Rosacea

In the present investigation, a nanoemulgel of minocycline was formulated and optimized for an improved drug delivery and longer retention time in the targeted area. Combining eucalyptus oil, Tween 20, and Transcutol HP, different o/w nanoemulsions were formulated by the oil phase titration method a...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2022-10, Vol.14 (11), p.2322
Main Authors: Siddiqui, Ayesha, Jain, Pooja, Alex, Thompson Santosh, Ali, Mohammed Asgar, Hassan, Nazia, Haneef, Jamshed, Naseef, Punnoth Poonkuzhi, Kuruniyan, Mohamed Saheer, Mirza, Mohd. Aamir, Iqbal, Zeenat
Format: Article
Language:English
Subjects:
Acne
Acne rosacea
Carbopol 940
Dosage and administration
Drug therapy
eucalyptus oil
Gels (Pharmacy)
Metabolism
Minocycline
Nanoemulsions
Nanotechnology
o/w nanoemulsion
permeation study
Ratios
Rosacea
Surfactants
Testing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the present investigation, a nanoemulgel of minocycline was formulated and optimized for an improved drug delivery and longer retention time in the targeted area. Combining eucalyptus oil, Tween 20, and Transcutol HP, different o/w nanoemulsions were formulated by the oil phase titration method and optimized by pseudo-ternary phase diagrams. The morphology, droplet size, viscosity, and refractive index of the thermodynamically stable nanoemulsion were determined. Furthermore, optimized nanoemulsion was suspended in 1.0% w/v of Carbopol 940 gel to formulate the nanoemulgel, and for this, pH, viscosity, and spreadability were determined and texture analysis was performed. To compare the extent of drug penetration between nanoemulsion and nanoemulgel, ex vivo skin permeation studies were conducted with Franz diffusion cell using rat skin as the permeation membrane, and the nanoemulgel exhibited sustained-release behavior. It can be concluded that the suggested minocycline-containing naoemulgel is expected to treat acne rosacea more effectively.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14112322