Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

• Published in: Journal of nanobiotechnology 2019-04, Vol.17 (1), p.55-55, Article 55
• Main Authors: Zhu, Wen-Qing, Shao, Shui-Yi, Xu, Li-Na, Chen, Wan-Qing, Yu, Xiao-Yu, Tang, Kai-Ming, Tang, Ze-Hua, Zhang, Fa-Ming, Qiu, Jing
• Format: Article
• Language: English
• Subjects: Adhesion; Alloys; Antioxidants; Antioxidants (Nutrients); Aqueous solutions; Biocompatibility; Biomedical materials; Chemical composition; Corrosion; Corrosion (Chemistry); Corrosion behavior; Corrosion cell; Corrosion potential; Corrosion resistance; Corrosion tests; Dental materials; Dental prosthetics; Dentistry; Diabetes; Enzymes; Etching; Exposure; Friction; Genes; Hydrogen peroxide; Macrophage; Macrophages; Metabolites; Metals (Materials); Nanoparticles; Nanotechnology; Nanowires; Organic chemistry; Osseointegration; Oxidation; Oxidation-reduction reactions; Oxidative stress; Oxidizing condition; Physiological aspects; Properties; Properties (attributes); Sandblasting; Scanning electron microscopy; Specialty metals industry; Steel corrosion; Surgical implants; Titanium; Titanium alloys; Topography; Toxicity; Transplants & implants; Zinc
• ISSN: 1477-3155; 1477-3155
• DOI: 10.1186/s12951-019-0488-9

Titanium (Ti) and its alloys as bio-implants have excellent biocompatibilities and osteogenic properties after modification of chemical composition and topography via various methods. The corrosion resistance of these modified materials is of great importance for changing oral system, while few researches have reported this point. Recently, oxidative corrosion induced by cellular metabolites has been well concerned. In this study, we explored the corrosion behaviors of four common materials (commercially pure Ti, cp-Ti; Sandblasting and acid etching-modified Ti, Ti-SLA; nanowires-modified Ti, Ti-NW; and zinc-containing nanowires-modified Ti, Ti-NW-Zn) with excellent biocompatibilities and osteogenic capacities under the macrophages induced-oxidizing microenvironment. The results showed that the materials immersed into a high oxidizing environment were more vulnerable to corrode. Meanwhile, different surfaces also showed various corrosion susceptibilities under oxidizing condition. Samples embed with zinc element exhibited more excellent corrosion resistance compared with other three surfaces exposure to excessive H O . Besides, we found that zinc-decorated Ti surfaces inhibited the adhesion and proliferation of macrophages on its surface and induced the M2 states of macrophages to better healing and tissue reconstruction. Most importantly, zinc-decorated Ti surfaces markedly increased the expressions of antioxidant enzyme relative genes in macrophages. It improved the oxidation microenvironment around the materials and further protected their properties. In summary, our results demonstrated that Ti-NW-Zn surfaces not only provided excellent corrosion resistance properties, but also inhibited the adhesion of macrophages. These aspects were necessary for maintaining osseointegration capacity and enhancing the corrosion resistance of Ti in numerous medical applications, particularly in dentistry.