Risk factors for cytomegalovirus disease in systemic lupus erythematosus (SLE): a systematic review

Cytomegalovirus (CMV) is an opportunistic pathogen causing reactivation and disease in Systemic Lupus Erythematosus (SLE) patients. This study aims to systematically review the literature for risk factors associated with CMV disease in SLE patients, in order to identify those more susceptible to CMV...

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Bibliographic Details
Published in:Advances in rheumatology (London, England) England), 2019-03, Vol.59 (1), p.12-12, Article 12
Main Authors: Choo, Hui Min Charlotte, Cher, Wen Qi, Kwan, Yu Heng, Fong, Warren Weng Seng
Format: Article
Language:English
Subjects:
Adult
Age
Asymptomatic
Autoimmune diseases
Biopsy
Creatinine
Cytomegalovirus
Cytomegalovirus - physiology
Cytomegalovirus infection
Cytomegalovirus Infections - etiology
Cytomegalovirus Infections - virology
Disease
Drug development
Female
Fungal infections
Gender
Humans
Immunosuppressive agents
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - adverse effects
Lavage
Leukopenia
Lupus
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - drug therapy
Lymphopenia - complications
Male
Middle Aged
Mortality
Opportunist infection
Pathogens
Pneumonia
Quality control
Rheumatic diseases
RHEUMATOLOGY
Risk Factors
Steroids - administration & dosage
Steroids - adverse effects
Systematic review
Systemic lupus erythematosus
Systemic lupus erythematosus (SLE)
Time Factors
Viral Load
Virus Activation
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Description
Summary:Cytomegalovirus (CMV) is an opportunistic pathogen causing reactivation and disease in Systemic Lupus Erythematosus (SLE) patients. This study aims to systematically review the literature for risk factors associated with CMV disease in SLE patients, in order to identify those more susceptible to CMV infection during their treatment. A systematic review was conducted on 4 different search engines and via hand search until May 2017. Studies were included after quality assessment via the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields (HTA KMET). Two studies on CMV disease were included. Elevated CMV viral load, higher steroid doses, use of immunosuppressants and disease duration were the most commonly associated risk factors for CMV disease. High CMV viral loads, longer SLE disease duration and higher steroid doses were associated with CMV disease. Further studies studying the risk of treatment drugs and role of interventions in the development of CMV infection are needed.
ISSN:2523-3106
2523-3106
DOI:10.1186/s42358-019-0055-y