The effect of direct application of dexamethasone on the round window membrane in patients with sudden sensorineural hearing loss

Objective The aim of this study was to test the effect of direct application of dexamethasone on the round window (RW) after its adequate exposure following a transcanal approach in patients with sudden sensorineural hearing loss (SSNHL). Study design This investigation was designed to be a prospect...

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Bibliographic Details
Published in:The Egyptian journal of otolaryngology 2017-10, Vol.33 (4), p.631-636
Main Authors: Abdel Baki, Fatthi A., Omran, Ahmed A., Asal, Samir I., Hassan, Khaled M.
Format: Article
Language:English
Subjects:
Care and treatment
Dexamethasone
Dosage and administration
General anesthesia
Glucocorticoids
Hearing loss
Medicine & Public Health
Original Article
round window
Steroids
sudden hearing loss
Surgery
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Summary:Objective The aim of this study was to test the effect of direct application of dexamethasone on the round window (RW) after its adequate exposure following a transcanal approach in patients with sudden sensorineural hearing loss (SSNHL). Study design This investigation was designed to be a prospective cohort study. Patients and methods This study included eighteen adult patients with SSNHL who attended our outpatient clinic at Alexandria Main University Hospital between 1 July 2015 and 1 July 2016. Under general anesthesia the small tympanomeatal flap was elevated to visualize the RW. If it was fully exposed, dexamethasone (4 mg/ml) was applied directly over a piece of gel foam; if not fully exposed the overhang was removed first and then dexamethasone was applied. After 2 weeks, a repeat audiogram was taken in all patients in order to evaluate the efficacy of the treatment on their hearing ability. Results Post-treatment assessment revealed 50% of patients with variable levels of improvement, whereas 50% did not respond to the given treatment. Of the patients showing improvement, 16.7% had normal hearing levels restored. Thus, direct application of dexamethasone on the RW membrane after its adequate exposure may reverse the hearing deficits in a few patients with SSNHL. Conclusion There is a definitive improvement in hearing in patients with SSNHL on direct application of dexamethasone on the RW membrane after its adequate exposure in patients.
ISSN:1012-5574
2090-8539
DOI:10.4103/ejo.ejo_49_17