Enkephalinase activity is modified and correlates with fatty acids in frontal cortex depending on fish, olive or coconut oil used in the diet

Enkephalins are neuropeptides involved in functions such as pain modulation and/ or cognitive processes. It has been reported that dietary fat modifies enkephalins in the brain. Since enkephalins are hydrolyzed by enkephalinases, the study of the influence of dietary fats, differing in their degree...

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Published in:Endocrine regulations (Bratislava) 2019-04, Vol.53 (2), p.59-64
Main Authors: Segarra, Ana B., Prieto, Isabel, Martinez-Canamero, Magdalena, Ruiz-Sanz, Jose-Ignacio, Ruiz-Larrea, M. Begona, De Gasparo, Marc, Banegas, Inmaculada, Zorad, Stefan, Ramirez-Sanchez, Manuel
Format: Article
Language:English
Subjects:
Animals
Brain Chemistry - drug effects
Coconut Oil - pharmacology
Diet
Dietary Fats - pharmacology
enkephalinases
enkephalins
fatty acids
Fatty Acids - metabolism
Fish Oils - pharmacology
frontal cortex
Frontal Lobe - drug effects
Frontal Lobe - metabolism
Lipid Metabolism - drug effects
Male
Neprilysin - drug effects
Neprilysin - metabolism
Olive Oil - pharmacology
Rats
Rats, Wistar
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creator Segarra, Ana B.
Prieto, Isabel
Martinez-Canamero, Magdalena
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Banegas, Inmaculada
Zorad, Stefan
Ramirez-Sanchez, Manuel
description Enkephalins are neuropeptides involved in functions such as pain modulation and/ or cognitive processes. It has been reported that dietary fat modifies enkephalins in the brain. Since enkephalins are hydrolyzed by enkephalinases, the study of the influence of dietary fats, differing in their degree of saturation, on brain fatty acids content and enkephalinase activity is important to understand its regulatory role on neuropeptides under different type of diets. We analyzed enkephalinase activity, assayed with alanine-β-naphthylamide as sub-strate, in frontal cortex of adult male rats fed diets supplemented with fish oil, olive oil or coconut oil, which markedly differed in the saturation of their fatty acids. Rats fed a diet enriched with coconut oil had lower enkephalinase activity than the group fed olive oil (p
doi_str_mv 10.2478/enr-2019-0007
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subjects Animals
Brain Chemistry - drug effects
Coconut Oil - pharmacology
Diet
Dietary Fats - pharmacology
enkephalinases
enkephalins
fatty acids
Fatty Acids - metabolism
Fish Oils - pharmacology
frontal cortex
Frontal Lobe - drug effects
Frontal Lobe - metabolism
Lipid Metabolism - drug effects
Male
Neprilysin - drug effects
Neprilysin - metabolism
Olive Oil - pharmacology
Rats
Rats, Wistar
title Enkephalinase activity is modified and correlates with fatty acids in frontal cortex depending on fish, olive or coconut oil used in the diet
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