Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

Ancient genomics can directly detect human genetic adaptation to environmental cues. However, it remains unclear how pathogens have exerted selective pressures on human genome diversity across different epochs and affected present-day inflammatory disease risk. Here, we use an ancestry-aware approxi...

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Published in:Cell genomics 2023-02, Vol.3 (2), p.100248, Article 100248
Main Authors: Kerner, Gaspard, Neehus, Anna-Lena, Philippot, Quentin, Bohlen, Jonathan, Rinchai, Darawan, Kerrouche, Nacim, Puel, Anne, Zhang, Shen-Ying, Boisson-Dupuis, Stéphanie, Abel, Laurent, Casanova, Jean-Laurent, Patin, Etienne, Laval, Guillaume, Quintana-Murci, Lluis
Format: Article
Language:English
Subjects:
ancient DNA
antagonistic pleiotropy
approximate Bayesian computation
Biodiversity
Genetics
host defense
Human genetics
immunity
infectious diseases
inflammatory disorders
LBP
Life Sciences
local adaptation
natural selection
Populations and Evolution
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Summary:Ancient genomics can directly detect human genetic adaptation to environmental cues. However, it remains unclear how pathogens have exerted selective pressures on human genome diversity across different epochs and affected present-day inflammatory disease risk. Here, we use an ancestry-aware approximate Bayesian computation framework to estimate the nature, strength, and time of onset of selection acting on 2,879 ancient and modern European genomes from the last 10,000 years. We found that the bulk of genetic adaptation occurred after the start of the Bronze Age,
ISSN:2666-979X
2666-979X
DOI:10.1016/j.xgen.2022.100248