Antioxidant Evaluation of the Aqueous Extract of Hulls of Campsiandra laurifolia in Colitis Induced by Acetic Acid in Wistar Rats

• Published in: Journal of Coloproctology 2021-06, Vol.41 (2), p.138-144
• Main Authors: Souza, Lucas Petitemberte de, Fillmann, Henrique Sarubbi, Fonseca, Sandielly Rebeca Benitez da, Brasil, Marilda da Silva, Marroni, Norma Anair Possa, Ferraz, Alexandre de Barros Falcão
• Format: Article
• Language: English
• Subjects: antioxidant; colitis; GASTROENTEROLOGY & HEPATOLOGY; Original Article | Artigo Original; oxidative stress; SURGERY; tannins
• ISSN: 2237-9363; 2317-6423; 2317-6423
• DOI: 10.1055/s-0041-1730258

Abstract Due to the ethnopharmacological use of Campsiandra laurifolia (Fabaceae), popularly known as Acapurana, to treat wounds and ulcers, associated with the lack of alternative treatments for intestinal inflammations such as ulcerative colitis (UC), the present work sought to characterize its phytochemical and antioxidant activities, and to evaluate remedial action in experimental colitis with acetic acid. Phytochemical analyzes were performed through qualitative and quantitative colorimetric tests of the main secondary metabolites. In the colitis model, 24 male Wistar rats aged ± 60 days old were used, divided into 4 groups: Control (CO) control + aqueous extract of C. laurifolia 50 mg/kg (CO + A50); Colitis (CL); and Colitis + aqueous extract of C. laurifolia 50 mg/kg (CL + A50). Measurement of sphincter anal pressure and histological tests of the large intestine, lipoperoxidation (LPO), enzyme activity of superoxide dismutase (SOD), and levels of glutathione (GSH) were performed. For statistical analysis, the oxidative stress (OS) results were expressed as means ± standard error, adopting a significance level of p